AM-8191 HCl

• 常用名: AM-8191 HCl
• 英文名: AM-8191 HCl
• CAS号: 1417548-17-4
• 分子量: 545.99
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₉ClFN₅O₅
• 熔点: N/A
• 闪点: N/A

AM-8191 HCl用途

AM-8191是一种细菌拓扑异构酶抑制剂,具有广谱抗菌活性。

AM-8191 HCl名称

• 英文名: AM-8191 HCl

AM-8191 HCl生物活性

• 描述: AM-8191是一种细菌拓扑异构酶抑制剂,具有广谱抗菌活性。
• 参考文献: 1. Singh SB, Kaelin DE, Wu J, Miesel L, Tan CM, Meinke PT, Olsen DB, Lagrutta A, Wei C, Liao Y, Peng X, Wang X, Fukuda H, Kishii R, Takei M, Yajima M, Shibue T, Shibata T, Ohata K, Nishimura A, Fukuda Y. Structure activity relationship of pyridoxazinone substituted RHS analogs of oxabicyclooctane-linked; 1,5-naphthyridinyl novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-6). Bioorg Med Chem Lett. 2015 Sep 1;25(17):3636-43. doi: 10.1016/j.bmcl.2015.06.057. Epub 2015 Jun 19. PubMed PMID: 26141771.

AM-8191 HCl物理化学性质

• 分子式: C₂₆H₂₉ClFN₅O₅
• 分子量: 545.99
• InChIKey: WDWFTZSOSPERQG-JKLZSTNZSA-N
• SMILES: COc1ccc2ncc(F)c(CC(O)C34CCC(NCc5ccc6c(n5)NC(=O)CO6)(CC3)CO4)c2n1.Cl

AM-8191 HCl靶点实验

查看更多实验

实验名称：Unbound fraction in dog plasma 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3295918

实验名称：Unbound fraction in human plasma 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3295917

实验名称：Metabolic stability in human liver microsomes after 30 to 60 mins 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3295920

实验名称：Unbound fraction in mouse plasma 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3295919

实验名称：Metabolic stability in dog liver microsomes after 30 to 60 mins 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3295644

实验名称：Metabolic stability in mouse liver microsomes after 30 to 60 mins 来源：ChEMBL 靶标：Liver External Id：CHEMBL3295643

实验名称：Antibacterial activity against Escherichia coli infected in iv dosed ICR mouse assess... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL3295646

实验名称：Antibacterial activity against Staphylococcus aureus infected in po dosed ICR mouse a... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL3295645

实验名称：Dose normalized AUC in C57BL/6 mouse at 1 mg/kg, iv and 2 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3295648

实验名称：Antibacterial activity against Escherichia coli infected in po dosed ICR mouse assess... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL3295647

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