2-Propenamide, N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-yl-2-pyrimidinyl)amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]

• 常用名: 2-Propenamide, N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-yl-2-pyrimidinyl)amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]
• 英文名: 2-Propenamide, N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-yl-2-pyrimidinyl)amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]
• CAS号: 1421373-43-4
• 分子量: 521.0
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₉ClN₈O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 2-Propenamide, N-[5-[(5-chloro-4-pyrazolo[1,5-a]pyridin-3-yl-2-pyrimidinyl)amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]

物理化学性质

• 分子式: C₂₆H₂₉ClN₈O₂
• 分子量: 521.0
• InChIKey: IEPKZTQXMCCRFJ-UHFFFAOYSA-N
• SMILES: C=CC(=O)Nc1cc(Nc2ncc(Cl)c(-c3cnn4ccccc34)n2)c(OC)cc1N(C)CCN(C)C

靶点实验

查看更多实验

实验名称：Intrinsic clearance in rat hepatocytes measured per 10'6 cells 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL3389040

实验名称：Unbound fraction in nude mouse plasma 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3389039

实验名称：Half life of the compound by GSH reduction assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL3389042

实验名称：Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M d... 来源：ChEMBL 靶标：NCI-H1975 External Id：CHEMBL5577191

实验名称：Intrinsic clearance in human hepatocytes measured per 10'6 cells 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL3389041

实验名称：Dissociation constant, pKa of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL3389043

实验名称：Intrinsic clearance in human hepatocytes 来源：ChEMBL 靶标：N/A External Id：CHEMBL5577194

实验名称：Cmax in mouse at 10 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3389049

实验名称：Ratio of free cmax in mouse at 10 mg/kg, po to IC50 for EGFR exon 19 deletion activat... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3389052

实验名称：Ratio of free cmax in mouse at 10 mg/kg, po to IC50 for EGFR L858R/T970M double mutan... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3389051

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