N-(5-{[5-Chloro-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}-2-{2-dimethylaminoethyl-methylamino}-4-methoxyphenyl)prop-2-enamide

• 常用名: N-(5-{[5-Chloro-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}-2-{2-dimethylaminoethyl-methylamino}-4-methoxyphenyl)prop-2-enamide
• 英文名: N-(5-{[5-Chloro-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}-2-{2-dimethylaminoethyl-methylamino}-4-methoxyphenyl)prop-2-enamide
• CAS号: 1421373-63-8
• 分子量: 534.1
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₃₂ClN₇O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-(5-{[5-Chloro-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}-2-{2-dimethylaminoethyl-methylamino}-4-methoxyphenyl)prop-2-enamide

物理化学性质

• 分子式: C₂₈H₃₂ClN₇O₂
• 分子量: 534.1
• InChIKey: DCVITXJMCYHCFL-UHFFFAOYSA-N
• SMILES: C=CC(=O)Nc1cc(Nc2ncc(Cl)c(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C

靶点实验

查看更多实验

实验名称：AUC in mouse at 10 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3390228

实验名称：Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M d... 来源：ChEMBL 靶标：NCI-H1975 External Id：CHEMBL5577191

实验名称：Intrinsic clearance in human hepatocytes measured per 10'6 cells 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL3389041

实验名称：Antiproliferative activity against human PC-9 cells harboring EGFR del19 mutant asses... 来源：ChEMBL 靶标：PC-9 External Id：CHEMBL5577195

实验名称：Antiproliferative activity against human LoVo cells harboring wild-type EGFR assessed... 来源：ChEMBL 靶标：LoVo External Id：CHEMBL5577196

实验名称：Inhibition of hERG 来源：ChEMBL 靶标：Voltage-gated inwardly rectifying potassium channel KCNH2 External Id：CHEMBL5577197

实验名称：Cmax in mouse at 10 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3389049

实验名称：Inhibition of EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells... 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL3389020

实验名称：Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluor... 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL3389022

实验名称：Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 ce... 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL3389021

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