6-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[(5-chloro-6-methyl-2-pyridinyl)amino]-3-pyridazinecarboxamide

• 常用名: 6-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[(5-chloro-6-methyl-2-pyridinyl)amino]-3-pyridazinecarboxamide
• 英文名: 6-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[(5-chloro-6-methyl-2-pyridinyl)amino]-3-pyridazinecarboxamide
• CAS号: 1446790-64-2
• 分子量: 375.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₂ClN₇O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 6-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[(5-chloro-6-methyl-2-pyridinyl)amino]-3-pyridazinecarboxamide

物理化学性质

• 分子式: C₁₇H₂₂ClN₇O
• 分子量: 375.9
• InChIKey: RPLRVRTUXULVOV-NWDGAFQWSA-N
• SMILES: Cc1nc(Nc2cc(NC3CCCCC3N)nnc2C(N)=O)ccc1Cl

靶点实验

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实验名称：Total plasma clearance in mouse at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3240922

实验名称：Metabolic stability in mouse liver microsomes 来源：ChEMBL 靶标：Liver External Id：CHEMBL3240921

实验名称：Apparent terminal half life in mouse at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3240924

实验名称：Volume of distribution at steady state in mouse at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3240923

实验名称：Dose-normalized AUC in mouse at 30 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3240926

实验名称：Oral bioavailability in mouse at 30 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3240928

实验名称：Dose-normalized AUC in mouse at 5 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3240927

实验名称：Oral bioavailability in mouse at 5 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3240929

实验名称：Mutagenicity in Salmonella typhi TA1537 by Ames test 来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhi External Id：CHEMBL3241042

实验名称：Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubat... 来源：ChEMBL 靶标：Tyrosine-protein kinase SYK External Id：CHEMBL3240906

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