N-{2-[5-(4-{[(4,6-Diaminopyrimidin-2-Yl)sulfanyl]methyl}-5-Propyl-1,3-Thiazol-2-Yl)-2-Methoxyphenoxy]ethyl}methanesulfonamide

• 常用名: N-{2-[5-(4-{[(4,6-Diaminopyrimidin-2-Yl)sulfanyl]methyl}-5-Propyl-1,3-Thiazol-2-Yl)-2-Methoxyphenoxy]ethyl}methanesulfonamide
• 英文名: N-{2-[5-(4-{[(4,6-Diaminopyrimidin-2-Yl)sulfanyl]methyl}-5-Propyl-1,3-Thiazol-2-Yl)-2-Methoxyphenoxy]ethyl}methanesulfonamide
• CAS号: 1450604-01-9
• 分子量: 524.7
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₈N₆O₄S₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-{2-[5-(4-{[(4,6-Diaminopyrimidin-2-Yl)sulfanyl]methyl}-5-Propyl-1,3-Thiazol-2-Yl)-2-Methoxyphenoxy]ethyl}methanesulfonamide

物理化学性质

• 分子式: C₂₁H₂₈N₆O₄S₃
• 分子量: 524.7
• InChIKey: VWMTUHOSEYDVPP-UHFFFAOYSA-N
• SMILES: CCCC1=C(N=C(S1)C2=CC(=C(C=C2)OC)OCCNS(=O)(=O)C)CSC3=NC(=CC(=N3)N)N

靶点实验

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实验名称：Inhibition of dCK in human CCRF-CEM cells assessed as inhibition of tritiated deoxycy... 来源：ChEMBL 靶标：Deoxycytidine kinase External Id：CHEMBL2429676

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：In vivo inhibition of dCK in C57BL/6 mouse using [18F]-L-FAC as substrate assessed as... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL2429678

实验名称：Apparent inhibition of human dCK assessed as phosphorylation activity by spectroscopi... 来源：ChEMBL 靶标：Deoxycytidine kinase External Id：CHEMBL3381704

实验名称：Inhibition of dCK in human CCRF-CEM cells assessed as inhibition of [3H]-dC uptake by... 来源：ChEMBL 靶标：Deoxycytidine kinase External Id：CHEMBL3381706

实验名称：Apparent inhibition of human dCK by steady-state kinetic assay 来源：ChEMBL 靶标：Deoxycytidine kinase External Id：CHEMBL3381705

实验名称：Half life in human liver microsomes at 1 uM after 30 mins in presence of NADPH 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3381708

实验名称：Intrinsic clearance in human liver microsomes at 1 uM after 30 mins in presence of NA... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3381707

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