MMV666810

更新时间：2026-07-15 11:35:53

MMV666810结构式	常用名	MMV666810	英文名	MMV666810
	CAS号	1450666-97-3	分子量	442.43
	密度	N/A	沸点	N/A
	分子式	C₂₃H₂₁F₃N₄O₂	熔点	N/A
	MSDS	N/A	闪点	N/A

MMV666810用途

MMV666810是一种类似于MMV390048的2-氨基吡嗪,在5.94 nM处对无性寄生虫有效,但对配子体,它对晚期配子体的选择性是早期配子体的3.3倍(早期配子体：IC50 603±88 nM；晚期配子体：IC50 179±8 nM)。

英文名	MMV666810

描述	MMV666810是一种类似于MMV390048的2-氨基吡嗪,在5.94 nM处对无性寄生虫有效,但对配子体,它对晚期配子体的选择性是早期配子体的3.3倍(早期配子体：IC50 603±88 nM；晚期配子体：IC50 179±8 nM)。
参考文献	[1]. Niemand J, et al. Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS Infect Dis. 2021 Oct 8;7(10):2904-2916.

分子式	C₂₃H₂₁F₃N₄O₂
分子量	442.43
InChIKey	FKDIWALLMXDOBS-UHFFFAOYSA-N
SMILES	Nc1ncc(-c2ccc(C(=O)N3CCC(O)CC3)cc2)nc1-c1ccc(C(F)(F)F)cc1

实验名称：Antiplasmodial activity against early stage (II/III) Plasmodium falciparum NF54 gamet...
来源：ChEMBL
靶标：Plasmodium falciparum
External Id：CHEMBL4719504

实验名称：Volume of distribution in Sprague-dawley rat at 3 mg/kg, iv by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4719498

实验名称：Clearance in Sprague-dawley rat at 3 mg/kg, iv by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4719496

实验名称：Antiplasmodial activity against luciferase expressing Plasmodium berghei sporozoites ...
来源：ChEMBL
靶标：Plasmodium berghei
External Id：CHEMBL4719502

实验名称：Antiplasmodial activity against late stage (IV/V) Plasmodium falciparum NF54 gametocy...
来源：ChEMBL
靶标：Plasmodium falciparum
External Id：CHEMBL4719503

实验名称：Oral bioavailability in Sprague-dawley rat at 10 mg/kg by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4719500

实验名称：Half-life in Sprague-dawley rat at 10 mg/kg, po by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4719492

实验名称：Half-life in Sprague-dawley rat at 3 mg/kg, iv by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4719493

实验名称：Antiplasmodial activity against Plasmodium berghei ANKA infected in NMRI mouse model ...
来源：ChEMBL
靶标：Plasmodium berghei
External Id：CHEMBL4719480

实验名称：Antiplasmodial activity against Plasmodium berghei ANKA infected in NMRI mouse model ...
来源：ChEMBL
靶标：Plasmodium berghei
External Id：CHEMBL4719481

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