1-[(1s)-1-(4-Chloro-3-Fluorophenyl)-2-Hydroxyethyl]-4-[2-(Tetrahydro-2h-Pyran-4-Ylamino)pyrimidin-4-Yl]pyridin-2(1h)-One

• 常用名: 1-[(1s)-1-(4-Chloro-3-Fluorophenyl)-2-Hydroxyethyl]-4-[2-(Tetrahydro-2h-Pyran-4-Ylamino)pyrimidin-4-Yl]pyridin-2(1h)-One
• 英文名: 1-[(1s)-1-(4-Chloro-3-Fluorophenyl)-2-Hydroxyethyl]-4-[2-(Tetrahydro-2h-Pyran-4-Ylamino)pyrimidin-4-Yl]pyridin-2(1h)-One
• CAS号: 1453847-30-7
• 分子量: 444.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₂ClFN₄O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1-[(1s)-1-(4-Chloro-3-Fluorophenyl)-2-Hydroxyethyl]-4-[2-(Tetrahydro-2h-Pyran-4-Ylamino)pyrimidin-4-Yl]pyridin-2(1h)-One

物理化学性质

• 分子式: C₂₂H₂₂ClFN₄O₃
• 分子量: 444.9
• InChIKey: PGGLRAWFUJMQBN-HXUWFJFHSA-N
• SMILES: O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1C(CO)c1ccc(Cl)c(F)c1

靶点实验

查看更多实验

实验名称：Inhibition of p90RSK phosphorylation in human HCT116 cells xenografted in nude mouse ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL3413973

实验名称：Antitumor activity against human HCT116 cells xenografted in nude mouse assessed as t... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3413974

实验名称：Inhibition of p90RSK phosphorylation in human HCT116 cells xenografted in nude mouse ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL3413972

实验名称：Inhibition of ERK1 (unknown origin) at 100 nM 来源：ChEMBL 靶标：Mitogen-activated protein kinase 3 External Id：CHEMBL3413977

实验名称：Inhibition of ERK2 (unknown origin) at 100 nM 来源：ChEMBL 靶标：Mitogen-activated protein kinase 1 External Id：CHEMBL3413978

实验名称：Toxicity in human HCT116 cells xenografted nude mouse assessed as body weight loss at... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3413975

实验名称：Agonist activity at adenosine A1 receptor (unknown origin) at 10 uM 来源：ChEMBL 靶标：Adenosine receptor A1 External Id：CHEMBL3413979

实验名称：ERK-2 Enzymatic Assay from US Patent US9259470: "Serine/threonine kinase inhibitors" 来源：BindingDB 靶标：N/A External Id：BindingDB_7622_1

实验名称：T>IC50 for inhibition of p90RSK phosphorylation in CD-1 mouse at 10 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4425959

实验名称：Thermodynamic solubility of the compound at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL3412895

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