NCGC 607

• 常用名: NCGC 607
• 英文名: NCGC 607
• CAS号: 1462267-07-7
• 分子量: 543.354
• 密度: 1.6±0.1 g/cm3
• 沸点: 734.5±60.0 °C at 760 mmHg
• 分子式: C₂₄H₂₂IN₃O₄
• 熔点: N/A
• 闪点: 398.0±32.9 °C

NCGC 607用途

NCGC607是葡萄糖脑苷酶(Gcase)的非抑制性伴侣[1]。

NCGC 607名称

• 英文名: NCGC607

NCGC 607生物活性

• 描述: NCGC607是葡萄糖脑苷酶(Gcase)的非抑制性伴侣[1]。
• 相关类别:
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Aflaki E, et al. A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism. J Neurosci. 2016 Jul 13;36(28):7441-52.

NCGC 607物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 734.5±60.0 °C at 760 mmHg
• 分子式: C₂₄H₂₂IN₃O₄
• 分子量: 543.354
• 闪点: 398.0±32.9 °C
• 精确质量: 543.065491
• LogP: 3.90
• InChIKey: HFVDMJQQAKLUSN-UHFFFAOYSA-N
• SMILES: CN(C(=O)CNC(=O)c1ccccc1OCC(=O)Nc1ccc(I)cc1)c1ccccc1
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.679

NCGC 607靶点实验

查看更多实验

实验名称：NCATS Kinetic Aqueous Solubility Profiling 来源：NCGC 靶标：N/A External Id：ADME-solubility1

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based... 来源：The Scripps Research Institute Molecular Screening Center 靶标：E3 ubiquitin-protein ligase UHRF1 isoform 1 [Homo sapiens] External Id：UHRF1-CPGDNA_INH_TRFRET_1536_1X%INH CSRUN for MBD2-CPGDNA INH

实验名称：Luminescence-based cell-based primary high throughput screening assay for inhibitors ... 来源：The Scripps Research Institute Molecular Screening Center 靶标：nuclear receptor subfamily 0 group B member 1 [Homo sapiens] External Id：DAX1-FULL_INH_LUMI_1536_1X%INH PRUN

实验名称：uHTS identification of small molecule modulators of Rev-erb Alpha. 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1016-RevErbaLBD-Primary-Assay

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] External Id：PLCB3_INH_QFRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：ADAM10 [Homo sapiens] External Id：ADAM10_INH_QFRET_1536_1X%INH PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Protein DAF-12, isoform a [Caenorhabditis elegans] External Id：HGDAF12_AG_LUMI_1536_1X%ACT PRUN

实验名称：NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) Profiling 来源：NCGC 靶标：N/A External Id：ADME-PAMPA1

实验名称：Epi Absorbance-based biochemical primary high throughput screening assay to identify ... 来源：The Scripps Research Institute Molecular Screening Center 靶标：tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] External Id：TPD2_INH_EPIABS_1536_1X%INH PRUN

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NCGC 607英文别名

• 2-{2-[(4-Iodophenyl)amino]-2-oxoethoxy}-N-{2-[methyl(phenyl)amino]-2-oxoethyl}benzamide
• NCGC607