CID-46943215

• 常用名: CID-46943215
• 英文名: CID-46943215
• CAS号: 1462267-08-8
• 分子量: 496.35
• 密度: 1.4±0.1 g/cm3
• 沸点: 724.2±60.0 °C at 760 mmHg
• 分子式: C₂₄H₂₂BrN₃O₄
• 熔点: N/A
• 闪点: 391.8±32.9 °C

CID-46943215用途

ML266是葡萄糖脑苷酶(GCase)分子伴侣,IC50为2.5µM。ML266与GCase结合,将突变蛋白运输到溶酶体,并恢复GCase的活性。ML266不抑制GCase酶的作用。ML266具有研究高切病的潜力【1】。

CID-46943215名称

• 英文名: 2-{2-[(4-Bromophenyl)amino]-2-oxoethoxy}-N-{2-[methyl(phenyl)amino]-2-oxoethyl}benzamide

CID-46943215生物活性

• 描述: ML266是葡萄糖脑苷酶(GCase)分子伴侣,IC50为2.5µM。ML266与GCase结合,将突变蛋白运输到溶酶体,并恢复GCase的活性。ML266不抑制GCase酶的作用。ML266具有研究高切病的潜力【1】。
• 相关类别:
  研究领域 >> 其他
• 参考文献:

  [1]. Rogers S, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7].

CID-46943215物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 724.2±60.0 °C at 760 mmHg
• 分子式: C₂₄H₂₂BrN₃O₄
• 分子量: 496.35
• 闪点: 391.8±32.9 °C
• 精确质量: 495.079376
• LogP: 3.47
• InChIKey: VAPWBKACLHRZBZ-UHFFFAOYSA-N
• SMILES: CN(C(=O)CNC(=O)c1ccccc1OCC(=O)Nc1ccc(Br)cc1)c1ccccc1
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.659

CID-46943215靶点实验

查看更多实验

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based... 来源：The Scripps Research Institute Molecular Screening Center 靶标：E3 ubiquitin-protein ligase UHRF1 isoform 1 [Homo sapiens] External Id：UHRF1-CPGDNA_INH_TRFRET_1536_1X%INH CSRUN for MBD2-CPGDNA INH

实验名称：Luminescence-based cell-based primary high throughput screening assay for inhibitors ... 来源：The Scripps Research Institute Molecular Screening Center 靶标：nuclear receptor subfamily 0 group B member 1 [Homo sapiens] External Id：DAX1-FULL_INH_LUMI_1536_1X%INH PRUN

实验名称：uHTS identification of small molecule modulators of Rev-erb Alpha. 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1016-RevErbaLBD-Primary-Assay

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] External Id：PLCB3_INH_QFRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：ADAM10 [Homo sapiens] External Id：ADAM10_INH_QFRET_1536_1X%INH PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Protein DAF-12, isoform a [Caenorhabditis elegans] External Id：HGDAF12_AG_LUMI_1536_1X%ACT PRUN

实验名称：Epi Absorbance-based biochemical primary high throughput screening assay to identify ... 来源：The Scripps Research Institute Molecular Screening Center 靶标：tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] External Id：TPD2_INH_EPIABS_1536_1X%INH PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] External Id：ABHD4_INH_FP_1536_1X%INH PRUN

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Phospholipase C, gamma 1 [Homo sapiens] External Id：PLCG1_INH_QFRET_1536_1X%INH PRUN

共18条，当前第1页，共2页

1

2

CID-46943215英文别名

• 2-{2-[(4-Bromophenyl)amino]-2-oxoethoxy}-N-{2-[methyl(phenyl)amino]-2-oxoethyl}benzamide
• CID-46943215