(2R,3s,4r,5r)-2-(羟基甲基)-5-(6-甲基-9h-嘌呤-9-基)四氢呋喃-3,4-二醇

• 常用名: (2R,3s,4r,5r)-2-(羟基甲基)-5-(6-甲基-9h-嘌呤-9-基)四氢呋喃-3,4-二醇
• 英文名: 9H-Purine, 6-methyl-9-b-D-ribofuranosyl
• CAS号: 14675-48-0
• 分子量: 266.25
• 密度: 1.81 g/cm3
• 沸点: 590.4ºC
• 分子式: C₁₁H₁₄N₄O₄
• 熔点: N/A
• 闪点: 310.9ºC

用途

6-甲基嘌呤核苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 中文名: (2R,3s,4r,5r)-2-(羟基甲基)-5-(6-甲基-9h-嘌呤-9-基)四氢呋喃-3,4-二醇
• 英文名: 6-methylpurine riboside

生物活性

• 描述: 6-甲基嘌呤核苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

物理化学性质

• 密度: 1.81 g/cm3
• 沸点: 590.4ºC
• 分子式: C₁₁H₁₄N₄O₄
• 分子量: 266.25
• 闪点: 310.9ºC
• 精确质量: 266.10200
• PSA: 113.52000
• InChIKey: FIGBCBGMUIGJBD-PNHWDRBUSA-N
• SMILES: Cc1ncnc2c1ncn2C1OC(CO)C(O)C1O
• 蒸汽压: 8.74E-15mmHg at 25°C
• 折射率: 1.796

靶点实验

查看更多实验

实验名称：Activity of Escherichia coli PNP assessed per mg of protein at 100 uM by UV spectrome... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1930345

实验名称：USP8 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 8 External Id：USP8 FAST DUB HTS Primary

实验名称：Cytotoxicity against human CCRF-CEM cells after 72 hrs by coulter counting 来源：ChEMBL 靶标：CCRF-CEM External Id：CHEMBL1930346

实验名称：USP17 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 17 like family member 5 External Id：USP17 FAST DUB HTS Primary

实验名称：USP7 deubiquitinase inhibition: Primary qHTS 来源：24642 靶标：ubiquitin specific peptidase 7 External Id：USP7 FAST DUB HTS Primary

实验名称：Tested for minimum cytotoxic concentration on virus-induced cytopathicity in E6SM cel... 来源：ChEMBL 靶标：E6SM External Id：CHEMBL671529

实验名称：Prodrug activation assessed as recombinant Escherichia coli PNP-mediated compound cle... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3755836

实验名称：Prodrug activation assessed as recombinant human PNP-mediated compound cleavage at 10... 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL3755834

实验名称：Prodrug activation assessed as recombinant Escherichia coli SAH/MTA hydrolase-mediate... 来源：ChEMBL 靶标：5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase External Id：CHEMBL3755981

实验名称：Prodrug activation assessed as recombinant Sulfolobus solfataricus MTAP-mediated comp... 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL3755839

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英文别名

• 6-Methylpurine ribonucleoside
• 6-D-MPR
• (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-methyl-9H-purin-9-yl)tetrahydrofuran-3,4-diol
• 6-methylpurine-riboside