QL-X-138

• 常用名: QL-X-138
• 英文名: QL-X-138
• CAS号: 1469988-63-3
• 分子量: 421.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₁₉N₅O₂
• 熔点: N/A
• 闪点: N/A

QL-X-138用途

QL-X-138是一种选择性和有效的BTK/MNK双激酶抑制剂,BTK,MNK1和MNK2的IC50分别为8,107.4和26 nM；表现出与BTK的共价结合和与MNK的非共价结合；增强抗增殖作用体外针对多种B细胞癌细胞系以及AML和CLL原发性患者细胞的功效；阻止细胞周期进程并强烈诱导细胞凋亡。

QL-X-138名称

• 英文名: QL-X-138

QL-X-138生物活性

• 描述: QL-X-138是一种选择性和有效的BTK/MNK双激酶抑制剂,BTK,MNK1和MNK2的IC50分别为8,107.4和26 nM；表现出与BTK的共价结合和与MNK的非共价结合；增强抗增殖作用体外针对多种B细胞癌细胞系以及AML和CLL原发性患者细胞的功效；阻止细胞周期进程并强烈诱导细胞凋亡。
• 参考文献: References 1. Wu H, et al. Leukemia. 2016 Jan;30(1):173-81. 2. Wang B, et al. Eur J Med Chem. 2017 Sep 8;137:545-557. View Related Products by Target MNK

QL-X-138物理化学性质

• 分子式: C₂₅H₁₉N₅O₂
• 分子量: 421.46
• InChIKey: JMVDIGHUQAXWIE-UHFFFAOYSA-N
• SMILES: C=CC(=O)Nc1cc(-n2c(=O)ccc3cnc4ccc(-c5cn[nH]c5)cc4c32)ccc1C

QL-X-138靶点实验

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实验名称：Inhibition of recombinant full length His-tagged human BTK expressed in baculovirus e... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4130920

实验名称：Inhibition of recombinant full length His-tagged human BMX expressed in baculovirus e... 来源：ChEMBL 靶标：Cytoplasmic tyrosine-protein kinase BMX External Id：CHEMBL4130921

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Binding Assay from US Patent US10000483: "Bone marrow on X chromosome kinase (BMX) in... 来源：BindingDB 靶标：N/A External Id：BindingDB_3455_2

实验名称：Irreversible inhibition of recombinant full length His-tagged human BTK expressed in ... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4130926

实验名称：In vitro Kinase Assay from US Patent US10000483: "Bone marrow on X chromosome kinase ... 来源：BindingDB 靶标：N/A External Id：BindingDB_3455_1

实验名称：Irreversible inhibition of recombinant full length His-tagged human BTK expressed in ... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4130925

实验名称：Inhibition of recombinant full length His-tagged human BLK expressed in baculovirus e... 来源：ChEMBL 靶标：Tyrosine-protein kinase Blk External Id：CHEMBL4130922

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Inhibition of recombinant GST-tagged human JAK3 expressed in baculovirus expression s... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK3 External Id：CHEMBL4130923

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