1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-hydroxyethanone

• 常用名: 1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-hydroxyethanone
• 英文名: 1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-hydroxyethanone
• CAS号: 14760-51-1
• 分子量: 480.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₃₃FN₂O₄
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1-[(1S,2R,13S,14S,17R,18S,20S)-7-(4-fluorophenyl)-17,20-dihydroxy-2,18-dimethyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-yl]-2-hydroxyethanone

物理化学性质

• 分子式: C₂₈H₃₃FN₂O₄
• 分子量: 480.6
• InChIKey: PGCWTDKPSMHVRB-LQHZEQFVSA-N
• SMILES: CC12Cc3cnn(-c4ccc(F)cc4)c3C=C1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)CO

靶点实验

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实验名称：Transactivation activity at glucocorticoid receptor in rat H4II-E cells assessed as i... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL2025284

实验名称：Transrepression activity at glucocorticoid receptor in human H292 cells assessed as i... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL2025285

实验名称：Transrepression activity at glucocorticoid receptor in human H292 cells assessed as i... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL2025282

实验名称：Transactivation activity at glucocorticoid receptor in human HepG2 cells assessed as ... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL2025283

实验名称：Transactivation activity at glucocorticoid receptor in human HepG2 cells assessed as ... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL2025286

实验名称：Transactivation activity at glucocorticoid receptor in rat H4II-E cells assessed as i... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL2025287

实验名称：Induction of translocation of human glucocorticoid receptor expressed in HEK293T cell... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL4680589

实验名称：Cytotoxicity against human REH cells overexpressing GR assessed as reduction in cell ... 来源：ChEMBL 靶标：REH External Id：CHEMBL4680590

实验名称：Induction of translocation of human glucocorticoid receptor expressed in HEK293T cell... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL4680592

实验名称：Cmax in po dosed rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL2025292

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