Benzamide, 4-[[6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-phenyl

• 常用名: Benzamide, 4-[[6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-phenyl
• 英文名: Benzamide, 4-[[6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-phenyl
• CAS号: 1482515-38-7
• 分子量: 458.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₁₉ClN₆O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: Benzamide, 4-[[6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]oxy]-N-phenyl

物理化学性质

• 分子式: C₂₄H₁₉ClN₆O₂
• 分子量: 458.9
• InChIKey: CNHCGAFMYXVVCT-UHFFFAOYSA-N
• SMILES: Cc1nn(C)cc1-c1nc2ncc(Cl)c(Oc3ccc(C(=O)Nc4ccccc4)cc3)c2[nH]1

靶点实验

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实验名称：Inhibition of full-length aurora-B (unknown origin) using 5FAMLRRASLG-CONH2 as substr... 来源：ChEMBL 靶标：Aurora kinase B External Id：CHEMBL3090781

实验名称：Inhibition of N-terminal HIS-tagged aurora-A (unknown origin) using 5FAM-LRRASLG-CONH... 来源：ChEMBL 靶标：Aurora kinase A External Id：CHEMBL3090782

实验名称：Oral bioavailability in Balb/C mouse at 5 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3090783

实验名称：Metabolic stability in human liver microsomes at 10 uM after 30 mins 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3090784

实验名称：Clearance in Balb/C mouse at 5 mg/kg, iv and po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3090785

实验名称：Ratio of IC50 for autophosphorylation of aurora-A T217E mutant at T288 in human HCT11... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3090488

实验名称：Ratio of IC50 for autophosphorylation of aurora-A T217E mutant at T288 in human HeLa ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3090493

实验名称：Volume of distribution in Balb/C mouse at 5 mg/kg, iv and po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3090496

实验名称：Metabolic stability in CD1 mouse liver microsomes at 10 uM after 30 mins 来源：ChEMBL 靶标：N/A External Id：CHEMBL3090497

实验名称：Inhibition of GSK3beta (unknown origin) at 1 uM 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL3090735

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