SB 204070

更新时间：2025-09-12 19:21:48

SB 204070结构式	常用名	SB 204070	英文名	SB 204070
	CAS号	148702-58-3	分子量	419.34
	密度	N/A	沸点	N/A
	分子式	C₁₉Cl₁H₂₇N₂O₄	熔点	243-245 °C(lit.)
	MSDS	美版	闪点	N/A

英文名	SB 204070

熔点	243-245 °C(lit.)
分子式	C₁₉Cl₁H₂₇N₂O₄
分子量	419.34
InChIKey	AOOSJYIINXVNHV-UHFFFAOYSA-N
SMILES	CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3c2OCCO3)CC1
外观性状	solid

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
WGK德国	3

Subepithelial trypsin induces enteric nerve-mediated anion secretion by activating proteinase-activated receptor 1 in the mouse cecum.

J. Physiol. Sci. 62(3) , 211-9, (2012)

Serine proteases are versatile signaling molecules and often exert this function by activating the proteinase-activated receptors (PAR(1)-PAR(4)). Our previous study on the mouse cecum has shown that ...

Evidence for 5-HT7 receptors mediating relaxation of human colonic circular smooth muscle.

Br. J. Pharmacol. 128(4) , 849-52, (1999)

5-HT4 receptors mediate relaxation of human colon circular muscle. However, after 5-HT4 receptor blockade (SB 204070 10 nM), 5-HT still induced a relaxation (pEC50 6.3). 5-HT4 receptors were sufficien...

The effects of SB 204070, a highly potent and selective 5-HT4 receptor antagonist, on guinea-pig distal colon.

Br. J. Pharmacol. 112(3) , 789-94, (1994)

1. The pharmacology of a novel 5-HT4 receptor antagonist, SB 204070 has been evaluated in the guinea-pig isolated distal colon longitudinal muscle-myenteric plexus (LMMP). 2. SB 204070 is a highly pot...

实验名称：Ex vivo receptor occupancy of 5HT4 receptor in rhesus monkey at 0.5 mg/kg
来源：ChEMBL
靶标：Macaca mulatta
External Id：CHEMBL3131848

实验名称：Acid dissociation constant was determined
来源：ChEMBL
靶标：N/A
External Id：CHEMBL638252

实验名称：Antagonist activity against 5-HT4 receptor mediated relaxation of rat carbachol contr...
来源：ChEMBL
靶标：5-hydroxytryptamine receptor 4
External Id：CHEMBL615279

实验名称：Compound was evaluated for its ability to inhibit the binding of 5-HT4 receptor radio...
来源：ChEMBL
靶标：5-hydroxytryptamine receptor 4
External Id：CHEMBL805839

实验名称：Compound was tested for binding affinity against 5-HT4 receptor in guinea pig striata...
来源：ChEMBL
靶标：5-hydroxytryptamine receptor 4
External Id：CHEMBL805838

实验名称：Ability to block 5-HT4 receptor mediated effect of 5-HT was assessed in the guinea-pi...
来源：ChEMBL
靶标：5-hydroxytryptamine receptor 4
External Id：CHEMBL805837

实验名称：Screen for inhibitors of RMI FANCM (MM2) intereaction
来源：11908
靶标：N/A
External Id：RMI-FANCM-MM2

实验名称：Binding affinity at 5HT3 receptor
来源：ChEMBL
靶标：5-hydroxytryptamine receptor 3A
External Id：CHEMBL964233

实验名称：Compound was tested against 5-HT4 receptor through antagonism of 5-HT mediated relaxa...
来源：ChEMBL
靶标：5-hydroxytryptamine receptor 4
External Id：CHEMBL802156

实验名称：Ability to antagonize 5-HT-evoked contractions mediated through 5-hydroxytryptamine 4...
来源：ChEMBL
靶标：5-hydroxytryptamine receptor 4
External Id：CHEMBL619089

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