(R)-6-(3-Hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-3-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide

• 常用名: (R)-6-(3-Hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-3-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide
• 英文名: (R)-6-(3-Hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-3-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide
• CAS号: 1492952-55-2
• 分子量: 433.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₈F₃N₅O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (R)-6-(3-Hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-3-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide

物理化学性质

• 分子式: C₂₀H₁₈F₃N₅O₃
• 分子量: 433.4
• InChIKey: LAOIFHGXIHOJNM-CQSZACIVSA-N
• SMILES: C1CN(C[C@@H]1O)C2=C(C=C(C=N2)C(=O)NC3=CC=C(C=C3)OC(F)(F)F)C4=CC=NN4

靶点实验

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实验名称：Half life in mouse at 1 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4200759

实验名称：Dissociation constant, pKa of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL4200743

实验名称：Lipophilicity, log p of the compound by high throughput assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL4200742

实验名称：Clearance in mouse at 1 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4200758

实验名称：Oral bioavailability in mouse at 30 mg/kg 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4200755

实验名称：Inhibition of ABL1 (64 to 515 residues)(unknown origin) expressed in Escherichia coli... 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL4200739

实验名称：Antitumor activity against human KCL22 cells xenografted in nude mouse assessed as tu... 来源：ChEMBL 靶标：KCL-22 External Id：CHEMBL4200770

实验名称：Tmax in mouse at 30 mg/kg, po 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4200752

实验名称：Inhibition of human ERG at 30 uM by manual patch clamp assay 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4200763

实验名称：Dose normalized AUC in mouse at 1 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4200747

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