Thiazolo[4,5-d]pyriMidin-2(3H)-one, 7-[[(1R)-1-(hydroxyMethyl)-3-Methylbutyl]aMino]-5-[[(1S)-1-phenylethyl]thio]

• 常用名: Thiazolo[4,5-d]pyriMidin-2(3H)-one, 7-[[(1R)-1-(hydroxyMethyl)-3-Methylbutyl]aMino]-5-[[(1S)-1-phenylethyl]thio]
• 英文名: Thiazolo[4,5-d]pyriMidin-2(3H)-one, 7-[[(1R)-1-(hydroxyMethyl)-3-Methylbutyl]aMino]-5-[[(1S)-1-phenylethyl]thio]
• CAS号: 15-58-7
• 分子量: 404.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₄N₄O₂S₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: Thiazolo[4,5-d]pyriMidin-2(3H)-one, 7-[[(1R)-1-(hydroxyMethyl)-3-Methylbutyl]aMino]-5-[[(1S)-1-phenylethyl]thio]

物理化学性质

• 分子式: C₁₉H₂₄N₄O₂S₂
• 分子量: 404.6
• InChIKey: IAGWEZFSRRPOSS-GXTWGEPZSA-N
• SMILES: CC(C)CC(CO)Nc1nc(SC(C)c2ccccc2)nc2[nH]c(=O)sc12

靶点实验

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实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301368

实验名称：Displacement of [125I]-CX3CL1 from human CX3CR1 transfected in HEK293 cells after 24 ... 来源：ChEMBL 靶标：CX3C chemokine receptor 1 External Id：CHEMBL2351085

实验名称：Displacement of [125I]-IL8 from human CXCR2 transfected in HEK293 cells after 4 hrs b... 来源：ChEMBL 靶标：C-X-C chemokine receptor type 2 External Id：CHEMBL2351084

实验名称：Selectivity ratio of Ki for human CXCR2 to Ki for human CX3CR1 来源：ChEMBL 靶标：N/A External Id：CHEMBL2351083

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301365

实验名称：Solubility of the compound in phosphate buffer at pH 7.4 after 24 hrs by HPLC analysi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2351082

实验名称：Metabolic stability in human liver microsomes assessed as intrinsic clearance by LC-M... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2351081

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301367

实验名称：Apparent permeability from apical to basolateral side in human Caco2 cells at pH 6.5 ... 来源：ChEMBL 靶标：Caco-2 External Id：CHEMBL2351080

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