N-[1-[(3R)-1-[(2E)-4-(Dimethylamino)-1-oxo-2-buten-1-yl]hexahydro-1H-azepin-3-yl]-7-methyl-1H-benzimidazol-2-yl]-2-methyl-4-pyridinecarboxamide

• 常用名: N-[1-[(3R)-1-[(2E)-4-(Dimethylamino)-1-oxo-2-buten-1-yl]hexahydro-1H-azepin-3-yl]-7-methyl-1H-benzimidazol-2-yl]-2-methyl-4-pyridinecarboxamide
• 英文名: N-[1-[(3R)-1-[(2E)-4-(Dimethylamino)-1-oxo-2-buten-1-yl]hexahydro-1H-azepin-3-yl]-7-methyl-1H-benzimidazol-2-yl]-2-methyl-4-pyridinecarboxamide
• CAS号: 1508250-74-5
• 分子量: 474.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₃₄N₆O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[1-[(3R)-1-[(2E)-4-(Dimethylamino)-1-oxo-2-buten-1-yl]hexahydro-1H-azepin-3-yl]-7-methyl-1H-benzimidazol-2-yl]-2-methyl-4-pyridinecarboxamide

物理化学性质

• 分子式: C₂₇H₃₄N₆O₂
• 分子量: 474.6
• InChIKey: SKLAQDNYYXAFGK-QWDXWUACSA-N
• SMILES: Cc1cc(C(=O)Nc2nc3cccc(C)c3n2C2CCCCN(C(=O)C=CCN(C)C)C2)ccn1

靶点实验

查看更多实验

实验名称：Clearance in balb/c mouse at 5 mg/kg, iv by liquid chromatography-tandem mass spectro... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3860384

实验名称：Antitumor activity against human NCI-H1975 cells xenografted in Foxn1 nude mouse asse... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3860400

实验名称：AUC in balb/c mouse at 20 mg/kg, po by liquid chromatography-tandem mass spectrometry 来源：ChEMBL 靶标：N/A External Id：CHEMBL3860385

实验名称：Oral bioavailability in balb/c mouse at 20 mg/kg by liquid chromatography-tandem mass... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3860386

实验名称：Toxicity in human NCI-H1975 cells xenografted Foxn1 nude mouse assessed as change in ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3860402

实验名称：Toxicity in human NCI-H1975 cells xenografted Foxn1 nude mouse assessed as change in ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3860403

实验名称：Time duration during which free plasma concentration stays above in-vitro IC50 level ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3860396

实验名称：Intrinsic clearance in human liver microsomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL3860382

实验名称：Intrinsic clearance in mouse liver microsomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL3860383

实验名称：Glutathione reactivity assessed as GSH adduct formation incubated for 1 hr using 10 m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3860393

共12条，当前第1页，共2页

1

2