N-[5-(2-Amino-4-methylpyrido[2,3-d]pyrimidin-6-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide

• 常用名: N-[5-(2-Amino-4-methylpyrido[2,3-d]pyrimidin-6-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide
• 英文名: N-[5-(2-Amino-4-methylpyrido[2,3-d]pyrimidin-6-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide
• CAS号: 1552301-52-6
• 分子量: 458.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₆F₂N₆O₃S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[5-(2-Amino-4-methylpyrido[2,3-d]pyrimidin-6-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide

物理化学性质

• 分子式: C₂₀H₁₆F₂N₆O₃S
• 分子量: 458.4
• InChIKey: PXMBVEZQNFLFAI-UHFFFAOYSA-N
• SMILES: COc1ncc(-c2cnc3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F

靶点实验

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实验名称：Inhibition of mTOR (unknown origin) assessed as inhibition of 4EBP-1 phosphorylation ... 来源：ChEMBL 靶标：Serine/threonine-protein kinase mTOR External Id：CHEMBL3380578

实验名称：Inhibition of recombinant human N-terminal GST-tagged PI3Kalpha expressed in baculovi... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL4220370

实验名称：Inhibition of mTOR (unknown origin) after 40 mins by TR-FRET assay 来源：ChEMBL 靶标：Serine/threonine-protein kinase mTOR External Id：CHEMBL3116931

实验名称：Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate compound preincub... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL3116932

实验名称：Ratio of PF-04691502 IC50 to compound IC50 for mTOR (unknown origin) after 40 mins by... 来源：ChEMBL 靶标：Serine/threonine-protein kinase mTOR External Id：CHEMBL3116922

实验名称：Ratio of PF-04691502 IC50 to compound IC50 for PI3Kalpha (unknown origin) using PIP2/... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL3116923

实验名称：Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate preincubated for ... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL3380577

实验名称：Antiproliferative activity against human U87MG cells after 4 days by Celltiter-Glo lu... 来源：ChEMBL 靶标：U-87 MG External Id：CHEMBL4220371

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