2-(4-羟基苯基)-2-氧代乙酸

• 常用名: 2-(4-羟基苯基)-2-氧代乙酸
• 英文名: 4-HYDROXYPHENYLGLYOXYLICACID
• CAS号: 15573-67-8
• 分子量: 166.13100
• 密度: 1.457g/cm3
• 沸点: 358.9ºC at 760mmHg
• 分子式: C₈H₆O₄
• 熔点: N/A
• 闪点: 185ºC

2-(4-羟基苯基)-2-氧代乙酸用途

4-Hydroxyphenglyoxylate (4-Hydroxyphenglyoxylic Acid) 是肉毒碱棕榈酰转移酶 I (CPT I) 的抑制剂。4-Hydroxyphenglyoxylate 可用于研究肝线粒体 CPT I 的敏感性变化和分离的肝细胞的脂肪酸氧化。4-Hydroxyphenglyoxylate 可以抑制脂肪酸氧化。

2-(4-羟基苯基)-2-氧代乙酸名称

• 中文名: 2-(4-羟基苯基)-2-氧代乙酸
• 英文名: 4-hydroxyphenylglyoxylic acid

2-(4-羟基苯基)-2-氧代乙酸生物活性

• 描述: 4-Hydroxyphenglyoxylate (4-Hydroxyphenglyoxylic Acid) 是肉毒碱棕榈酰转移酶 I (CPT I) 的抑制剂。4-Hydroxyphenglyoxylate 可用于研究肝线粒体 CPT I 的敏感性变化和分离的肝细胞的脂肪酸氧化。4-Hydroxyphenglyoxylate 可以抑制脂肪酸氧化。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Stephens TW, et al. Effect of starvation and diabetes on the sensitivity of carnitine palmitoyltransferase I to inhibition by 4-hydroxyphenylglyoxylate. Biochem J. 1987 Apr 15;243(2):405-12.

2-(4-羟基苯基)-2-氧代乙酸物理化学性质

• 密度: 1.457g/cm3
• 沸点: 358.9ºC at 760mmHg
• 分子式: C₈H₆O₄
• 分子量: 166.13100
• 闪点: 185ºC
• 精确质量: 166.02700
• PSA: 74.60000
• LogP: 0.65950
• InChIKey: KXFJZKUFXHWWAJ-UHFFFAOYSA-N
• SMILES: O=C(O)C(=O)c1ccc(O)cc1
• 蒸汽压: 8.95E-06mmHg at 25°C
• 储存条件: 室温

2-(4-羟基苯基)-2-氧代乙酸安全信息

• 海关编码: 2918990090

2-(4-羟基苯基)-2-氧代乙酸海关

• 海关编码: 2918990090
• 中文概述: 2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

2-(4-羟基苯基)-2-氧代乙酸靶点实验

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实验名称：Inhibition of wild type amyloid beta (1 to 42) (unknown origin) aggregation at 50 uM ... 来源：ChEMBL 靶标：Amyloid-beta precursor protein External Id：CHEMBL3750655

实验名称：Inhibition of human CPT1A 来源：ChEMBL 靶标：Carnitine O-palmitoyltransferase 1, liver isoform External Id：CHEMBL2217072

实验名称：Percent Stimulation of pyruvate oxidation in rat diaphragm by the compound was measur... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL794030

实验名称：Percent Stimulation of pyruvate oxidation in rat diaphragm was measured at 2 mM conce... 来源：ChEMBL 靶标：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial External Id：CHEMBL794031

实验名称：Pyruvate dehydrogenase active/ Pyruvate dehydrogenase total was measured by sc admini... 来源：ChEMBL 靶标：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial External Id：CHEMBL790247

实验名称：Pyruvate dehydrogenase activity in vivo was measured following subcutaneous administr... 来源：ChEMBL 靶标：[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial External Id：CHEMBL790250

实验名称：Inhibition of human CPT1B 来源：ChEMBL 靶标：Carnitine O-palmitoyltransferase 1, muscle isoform External Id：CHEMBL2217071

实验名称：Binding affinity to HFIP-treated 15N-labelled wild type Amyloid beta (1 to 42) monome... 来源：ChEMBL 靶标：Amyloid-beta precursor protein External Id：CHEMBL3750506

实验名称：Inhibition of human CPT2 来源：ChEMBL 靶标：Carnitine O-palmitoyltransferase 2, mitochondrial External Id：CHEMBL2217026

实验名称：Cytotoxicity in human KB cells 来源：ChEMBL 靶标：KB External Id：CHEMBL2217024

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2-(4-羟基苯基)-2-氧代乙酸英文别名

• (4-hydroxyphenyl)(oxo)acetic acid
• p-hydroxybenzoylformic acid
• 2-(4-hydroxyphenyl)-2-oxoacetic acid
• Pisolithin A
• p-hydroxyphenylpyruvic acid
• 2-(4-hydroxyphenyl)glyoxylic acid
• 4-Hydroxyphenylglyoxylate
• 4-hydroxybenzoylformate
• 4-Hydroxyphenylglyoxylicacid