6-[(1,3-Benzothiazol-6-yl)amino]-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide

• 常用名: 6-[(1,3-Benzothiazol-6-yl)amino]-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide
• 英文名: 6-[(1,3-Benzothiazol-6-yl)amino]-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide
• CAS号: 1610016-82-4
• 分子量: 431.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₆FN₅O₂S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 6-[(1,3-Benzothiazol-6-yl)amino]-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide

物理化学性质

• 分子式: C₂₁H₂₆FN₅O₂S
• 分子量: 431.5
• InChIKey: PXWXZTKRZLFCJV-GOSISDBHSA-N
• SMILES: CC(C)NC1=CC(=NC=C1C(=O)NC[C@H](C(C)(C)O)F)NC2=CC3=C(C=C2)N=CS3

靶点实验

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实验名称：Inhibition Assay from US Patent US9546153: "Bicyclic heterocycle substituted pyridyl ... 来源：BindingDB 靶标：N/A External Id：BindingDB_192_1

实验名称：Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as sub... 来源：ChEMBL 靶标：Interleukin-1 receptor-associated kinase 4 External Id：CHEMBL4625630

实验名称：Inhibition of IRAK4 in human whole blood assessed as inhibition of LTA-induced IL-6 p... 来源：ChEMBL 靶标：Interleukin-1 receptor-associated kinase 4 External Id：CHEMBL4625632

实验名称：Inhibition of IRAK4 in human PBMC assessed as inhibition of LTA-induced IL-6 producti... 来源：ChEMBL 靶标：Interleukin-1 receptor-associated kinase 4 External Id：CHEMBL4625631

实验名称：Stability in mouse liver microsomes assessed as parent compound remaining measured af... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4625634

实验名称：Stability in human liver microsomes assessed as parent compound remaining 来源：ChEMBL 靶标：N/A External Id：CHEMBL4625633

实验名称：Selectivity index, ratio of IC50 for N-terminal His6-tagged human full length recombi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4625635

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