Synaptamide

• 常用名: Synaptamide
• 英文名: Synaptamide
• CAS号: 162758-94-3
• 分子量: 371.556
• 密度: 1.0±0.1 g/cm3
• 沸点: 544.7±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₇NO₂
• 熔点: N/A
• 闪点: 283.3±30.1 °C

Synaptamide用途

Synaptamide是一种有效的调节剂，通过PKA/ CREB激活作用而对NSCs神经分化起作用。

Synaptamide名称

• 中文名: Synaptamide
• 英文名: Docosahexaenoyl ethanolamide

Synaptamide生物活性

• 描述: Synaptamide是一种有效的调节剂,通过PKA/ CREB激活作用而对NSCs神经分化起作用。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> PKA
  信号通路 >> 干细胞及 Wnt 通路 >> PKA
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Kim HY, et al. Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. Prostaglandins Leukot Essent Fatty Acids. 2013 Jan;88(1):121-5.

  [2]. Rashid MA, et al. N-Docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation. J Neurochem. 2013 Jun;125(6):869-84.

Synaptamide物理化学性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 544.7±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₇NO₂
• 分子量: 371.556
• 闪点: 283.3±30.1 °C
• 精确质量: 371.282440
• PSA: 49.33000
• LogP: 5.44
• InChIKey: GEEHOLRSGZPBSM-KUBAVDMBSA-N
• SMILES: CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)NCCO
• 蒸汽压: 0.0±3.3 mmHg at 25°C
• 折射率: 1.521
• 储存条件: -20°C

Synaptamide安全信息

• 危险品运输编码: NONH for all modes of transport

Synaptamide靶点实验

查看更多实验

实验名称：NCATS Kinetic Aqueous Solubility Profiling 来源：NCGC 靶标：N/A External Id：ADME-solubility1

实验名称：Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as in... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 2 External Id：CHEMBL4236714

实验名称：Induction of apoptosis in human 143B cells at 12.5 by Annexin V-FITC/propidium iodide... 来源：ChEMBL 靶标：143B External Id：CHEMBL4145146

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Induction of apoptosis in human MG63 cells at 12.5 by Annexin V-FITC/propidium iodide... 来源：ChEMBL 靶标：MG-63 External Id：CHEMBL4145147

实验名称：Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as in... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 2 External Id：CHEMBL4236713

实验名称：Induction of apoptosis in human HOS cells at 12.5 by Annexin V-FITC/propidium iodide ... 来源：ChEMBL 靶标：HOS External Id：CHEMBL4145148

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Growth inhibition of human A549 cells at 3 uM after 48 hrs by trypan blue dye exclusi... 来源：ChEMBL 靶标：A549 External Id：CHEMBL3371879

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Synaptamide英文别名

• (4Z,7Z,10Z,13Z,16Z,19Z)-N-(2-Hydroxyethyl)docosa-4,7,10,13,16,19-hexaenamide,DEA,DHEA
• (4Z,7Z,10Z,13Z,16Z,19Z)-N-(2-Hydroxyethyl)-4,7,10,13,16,19-docosahexaenamide
• N-(2-hydroxyethyl)docosa-4,7,10,13,16,19-hexaenamide
• Synaptamide