ARN 726

• 常用名: ARN 726
• 英文名: ARN 726
• CAS号: 1628343-77-0
• 分子量: 268.352
• 密度: 1.1±0.1 g/cm3
• 沸点: 478.8±34.0 °C at 760 mmHg
• 分子式: C₁₄H₂₄N₂O₃
• 熔点: N/A
• 闪点: 243.4±25.7 °C

ARN 726用途

ARN726是一种有效的,选择性的,口服生物可利用的N-酰基乙醇胺酸酰胺酶(NAAA)抑制剂,IC50为63 nM(r-NAAA)和27 nM(h-NAAA)；与28个生物学相关靶标组无相互作用。脂质代谢和炎症相关酶；在小鼠模型和小鼠模型中发挥深远的抗炎作用人巨噬细胞。

ARN 726名称

• 英文名: compound 6 [PMID: 25874594]

ARN 726生物活性

• 描述: ARN726是一种有效的,选择性的,口服生物可利用的N-酰基乙醇胺酸酰胺酶(NAAA)抑制剂,IC50为63 nM(r-NAAA)和27 nM(h-NAAA)；与28个生物学相关靶标组无相互作用。脂质代谢和炎症相关酶；在小鼠模型和小鼠模型中发挥深远的抗炎作用人巨噬细胞。
• 参考文献: References 1. Ribeiro A, et al. ACS Chem Biol. 2015 Aug 21;10(8):1838-46. 2. Bonezzi FT, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):656-63. View Related Products by Target Other Targets

ARN 726物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 478.8±34.0 °C at 760 mmHg
• 分子式: C₁₄H₂₄N₂O₃
• 分子量: 268.352
• 闪点: 243.4±25.7 °C
• 精确质量: 268.178680
• LogP: 1.88
• InChIKey: FNLUJRBWJBUJTC-LBPRGKRZSA-N
• SMILES: O=C(NC1CNC1=O)OCCCCC1CCCCC1
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.515

ARN 726靶点实验

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实验名称：Inhibition of human acid ceramidase by UPLC/MS analysis 来源：ChEMBL 靶标：Acid ceramidase External Id：CHEMBL3772812

实验名称：Inhibition of human NAAA expressed in HEK293 cells preincubated for 10 mins followed ... 来源：ChEMBL 靶标：N-acylethanolamine-hydrolyzing acid amidase External Id：CHEMBL3772811

实验名称：Inhibition of human NAAA 来源：ChEMBL 靶标：N-acylethanolamine-hydrolyzing acid amidase External Id：CHEMBL4612017

实验名称：Selectivity ratio of IC50 for human acid ceramidase to IC50 for recombinant human NAA... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3772810

实验名称：Inhibition of recombinant human NAAA expressed in HEK293 cells after 30 mins by UPLC/... 来源：ChEMBL 靶标：N-acylethanolamine-hydrolyzing acid amidase External Id：CHEMBL3772809

实验名称：Half life in rat plasma after 2 hrs by LC/MS-MS analysis 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3772816

实验名称：Half life in mouse liver microsomes preincubated for 15 mins followed by NADPH additi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3772815

实验名称：Half life in mouse plasma after 2 hrs by LC/MS-MS analysis 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3772814

实验名称：Inhibition of human FAAH at 10 uM by fluorescence assay 来源：ChEMBL 靶标：Fatty-acid amide hydrolase 1 External Id：CHEMBL3772813

实验名称：Kinetic solubility of the compound in PBS at pH 7.4 after 24 hrs by UPLC/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL3772818

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ARN 726英文别名

• compound 6 [PMID: 25874594]
• Carbamic acid, N-[(3S)-2-oxo-3-azetidinyl]-, 4-cyclohexylbutyl ester
• 4-Cyclohexylbutyl [(3S)-2-oxo-3-azetidinyl]carbamate