Mavoglurant外消旋

• 常用名: Mavoglurant外消旋
• 英文名: Mavoglurant racemate
• CAS号: 1636881-61-2
• 分子量: 313.391
• 密度: 1.2±0.1 g/cm3
• 沸点: 476.3±45.0 °C at 760 mmHg
• 分子式: C₁₉H₂₃NO₃
• 熔点: N/A
• 闪点: 241.8±28.7 °C

Mavoglurant外消旋用途

Mavoglurant racemate 是 mavoglurant 的外消旋体。Mavoglurant 是一种新颖的,非竞争性的 mGlu5 受体拮抗剂。

Mavoglurant外消旋名称

• 中文名: Mavoglurant外消旋
• 英文名: Mavoglurant racemate

Mavoglurant外消旋生物活性

• 描述: Mavoglurant racemate 是 mavoglurant 的外消旋体。Mavoglurant 是一种新颖的,非竞争性的 mGlu5 受体拮抗剂。
• 相关类别:
  研究领域 >> 其他
• 体外研究: 对于拮抗活性,(-)- mavoglurant,(-)-对映体显示IC50为0.11μM和0.03μM(Ca2 +和PI-周转),而(+)-对映体((+)- 10)仅显示37％和在10μM时抑制18％[1]。
• 参考文献:

  [1]. Vranesic I, et al. AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization. Bioorg Med Chem. 2014 Nov 1;22(21):5790-803

Mavoglurant外消旋物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 476.3±45.0 °C at 760 mmHg
• 分子式: C₁₉H₂₃NO₃
• 分子量: 313.391
• 闪点: 241.8±28.7 °C
• 精确质量: 313.167786
• LogP: 3.51
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.602
• 储存条件: 2-8℃

Mavoglurant外消旋靶点实验

查看更多实验

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Experimentally measured binding affinity data (Kd) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Kd for protein-ligand complexes

实验名称：Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 5 External Id：CHEMBL3606566

实验名称：Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells asse... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 5 External Id：CHEMBL3606567

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Intrinsic clearance in Sprague-Dawley rat liver microsomes after 45 mins by LC-MS/MS ... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3089420

实验名称：Intrinsic clearance in human liver microsomes after 45 mins by LC-MS/MS analysis 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3089421

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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Mavoglurant外消旋英文别名

• Methyl (3aR,4S,7aR)-4-hydroxy-4-[(3-methylphenyl)ethynyl]octahydro-1H-indole-1-carboxylate
• AFQ-056
• Mavoglurant
• MFCD18633263
• UNII:GT0I9SV4F6
• Mavoglurant (racemate)