4-[2-(1-carboxycyclopropyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]-2-(hydroxymethyl)Benzoic acid

• 常用名: 4-[2-(1-carboxycyclopropyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]-2-(hydroxymethyl)Benzoic acid
• 英文名: 4-[2-(1-carboxycyclopropyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]-2-(hydroxymethyl)Benzoic acid
• CAS号: 1643380-41-9
• 分子量: 383.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₇N₃O₆
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4-[2-(1-carboxycyclopropyl)-8-methoxy[1,2,4]triazolo[1,5-a]pyridin-5-yl]-2-(hydroxymethyl)Benzoic acid

物理化学性质

• 分子式: C₁₉H₁₇N₃O₆
• 分子量: 383.4
• InChIKey: RWRVDILQNIVFBM-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2ccc(C(=O)O)c(CO)c2)n2nc(C3(C(=O)O)CC3)nc12

靶点实验

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实验名称：Half life in human keratinocytes at 1 uM by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676340

实验名称：Half life in human whole blood at 0.1 uM by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676339

实验名称：Clearance in mini pig hepatocytes at 10 uM by UPLC/TOF-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676374

实验名称：Clearance in human hepatocytes at 10 uM by UPLC/TOF-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676373

实验名称：Clearance in rat hepatocytes at 10 uM by UPLC/TOF-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676375

实验名称：Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP... 来源：ChEMBL 靶标：cAMP-specific 3',5'-cyclic phosphodiesterase 4D External Id：CHEMBL4676336

实验名称：Clearance in human liver microsomes at 0.5 uM incubated for 40 mins in presence of NA... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676338

实验名称：Inhibition of PDE4D in human PBMC assessed as reduction in lipopolysaccharide-induced... 来源：ChEMBL 靶标：cAMP-specific 3',5'-cyclic phosphodiesterase 4D External Id：CHEMBL4676337

实验名称：AUC (0 to 24 hrs) in human patient with atopic dermatitis at 0.25% dosed topically as... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676388

实验名称：AUC (0 to 24 hrs) in cynomolgus monkey at 30 mg/kg, sc dosed as single administration 来源：ChEMBL 靶标：N/A External Id：CHEMBL4676387

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