5-[6-(5-Fluoro-2-pyridinyl)-4-pyrimidinyl]-1,3-benzenedicarbonitrile

• 常用名: 5-[6-(5-Fluoro-2-pyridinyl)-4-pyrimidinyl]-1,3-benzenedicarbonitrile
• 英文名: 5-[6-(5-Fluoro-2-pyridinyl)-4-pyrimidinyl]-1,3-benzenedicarbonitrile
• CAS号: 1644645-33-9
• 分子量: 301.28
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₈FN₅
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 5-[6-(5-Fluoro-2-pyridinyl)-4-pyrimidinyl]-1,3-benzenedicarbonitrile

物理化学性质

• 分子式: C₁₇H₈FN₅
• 分子量: 301.28
• InChIKey: ZSBXGUSZFWRANX-UHFFFAOYSA-N
• SMILES: N#Cc1cc(C#N)cc(-c2cc(-c3ccc(F)cn3)ncn2)c1

靶点实验

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实验名称：[3H]-M-MPEP Radioligand Binding Assay from US Patent US10584111: "4-(3-cyanophenyl)-6... 来源：BindingDB 靶标：N/A External Id：BindingDB_8997_1

实验名称：Radioligand Binding Assay from US Patent US11584732: "Methods of treatment using 4-(3... 来源：BindingDB 靶标：N/A External Id：BindingDB_11140_1

实验名称：Half life in rat liver microsomes 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3606568

实验名称：Clearance in rat at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3606569

实验名称：Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 5 External Id：CHEMBL3606566

实验名称：Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells asse... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 5 External Id：CHEMBL3606567

实验名称：Ratio of drug level in rat brain to plasma at 0.5 mg/kg, iv after 0.5 hrs 来源：ChEMBL 靶标：Nucleic Acid External Id：CHEMBL3606572

实验名称：Ratio of drug level in rat brain to plasma at 0.5 mg/kg, iv after 2 hrs 来源：ChEMBL 靶标：Nucleic Acid External Id：CHEMBL3606573

实验名称：Volume of distribution at steady state in rat at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3606570

实验名称：Half life in rat at 0.5 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3606571

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