4-乙炔-3-[3-氟-4-[(2-甲基-1H-咪唑并[4,5-c]吡啶-1-基)甲基]苯甲酰基]-N,N-二甲基-1H-吲哚-1-羧酰胺

• 常用名: 4-乙炔-3-[3-氟-4-[(2-甲基-1H-咪唑并[4,5-c]吡啶-1-基)甲基]苯甲酰基]-N,N-二甲基-1H-吲哚-1-羧酰胺
• 英文名: 4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-N,N-dimethylindole-1-carboxamide
• CAS号: 170499-15-7
• 分子量: 479.50500
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₂₂FN₅O₂
• 熔点: N/A
• 闪点: N/A

名称

• 中文名: 4-乙炔-3-[3-氟-4-[(2-甲基-1H-咪唑并[4,5-c]吡啶-1-基)甲基]苯甲酰基]-N,N-二甲基-1H-吲哚-1-羧酰胺
• 英文名: 4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-N,N-dimethylindole-1-carboxamide

物理化学性质

• 分子式: C₂₈H₂₂FN₅O₂
• 分子量: 479.50500
• 精确质量: 479.17600
• PSA: 73.02000
• LogP: 4.62380
• InChIKey: GDLNHSUSOZEAOR-UHFFFAOYSA-N
• SMILES: C#Cc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)c(F)c1)cn2C(=O)N(C)C

靶点实验

查看更多实验

实验名称：Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF a... 来源：ChEMBL 靶标：Platelet-activating factor receptor External Id：CHEMBL768491

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：The bioavailability in monkey was evaluated 来源：ChEMBL 靶标：N/A External Id：CHEMBL629607

实验名称：The bioavailability in rat was evaluated 来源：ChEMBL 靶标：N/A External Id：CHEMBL629688

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Tested in vivo for to block the effect of exogenously administered PAF upon oral admi... 来源：ChEMBL 靶标：Platelet-activating factor receptor External Id：CHEMBL784815

实验名称：Ability to block the effect of exogenously administered PAF upon intravenous administ... 来源：ChEMBL 靶标：Platelet-activating factor receptor External Id：CHEMBL784677

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

共17条，当前第1页，共2页

1

2

英文别名

• UNII-AYB44L739V
• 1-N,N-dimethylcarbamoyl-4-ethynyl-3-{3-fluoro-4-[(1H-2-methylimidazo-[4,5-c]pyrid-1-yl)methyl]benzoyl}indole
• 1H-Indole-1-carboxamide,4-ethynyl-3-(3-fluoro-4-((2-methyl-1H-imidazo(4,5-c)pyridin-1-yl)methyl)benzoyl)-N,N-dimethyl
• ABT-491 free base