Lotrafiban

• 常用名: Lotrafiban
• 英文名: Lotrafiban
• CAS号: 171049-14-2
• 分子量: 428.52500
• 密度: 1.22g/cm3
• 沸点: 730ºC at 760 mmHg
• 分子式: C₂₃H₃₂N₄O₄
• 熔点: N/A
• 闪点: 395.3ºC

Lotrafiban用途

洛拉非班是一种口服活性血小板GPIIb/IIIa阻滞剂,用于治疗冠状动脉和脑血管疾病。

Lotrafiban名称

• 英文名: 2-[(2S)-4-methyl-3-oxo-7-(4-piperidin-4-ylpiperidine-1-carbonyl)-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid

Lotrafiban生物活性

• 描述: 洛拉非班是一种口服活性血小板GPIIb/IIIa阻滞剂,用于治疗冠状动脉和脑血管疾病。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Topol EJ, Easton D, Harrington RA, et al. Randomized, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease. Circulation. 2003;108(4):399-406.

Lotrafiban物理化学性质

• 密度: 1.22g/cm3
• 沸点: 730ºC at 760 mmHg
• 分子式: C₂₃H₃₂N₄O₄
• 分子量: 428.52500
• 闪点: 395.3ºC
• 精确质量: 428.24200
• PSA: 101.98000
• LogP: 2.10820
• InChIKey: PYZOVVQJTLOHDG-FQEVSTJZSA-N
• SMILES: CN1Cc2cc(C(=O)N3CCC(C4CCNCC4)CC3)ccc2NC(CC(=O)O)C1=O
• 蒸汽压: 2.27E-22mmHg at 25°C
• 折射率: 1.572

Lotrafiban靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Duration of action in dog at a dose of 1 mg/kg i.d. 来源：ChEMBL 靶标：N/A External Id：CHEMBL629658

实验名称：qHTS assay to identify small molecule antagonists of the peroxisome proliferator-acti... 来源：824 靶标：N/A External Id：PPARGV841

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Lotrafiban英文别名

• Lotrafiban