磷酸萘酚喹

更新时间：2025-08-23 13:46:31

磷酸萘酚喹用途

Naphthoquine磷酸盐是抗疟疾化合物。

中文名	磷酸萘酚喹
英文名	2-[(tert-butylamino)methyl]-4-[(7-chloroquinolin-4-yl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol,phosphoric acid
英文别名	更多

描述	Naphthoquine磷酸盐是抗疟疾化合物。
相关类别	信号通路 >> 抗感染 >> 寄生物研究领域 >> 其他
参考文献	[1]. Qu HY, et al. Single-dose safety, pharmacokinetics, and food effects studies of compound naphthoquine phosphate tablets in healthy volunteers. J Clin Pharmacol. 2010 Nov;50(11):1310-8. [2]. Tun T, et al. Efficacy of oral single dose therapy with artemisinin-naphthoquine phosphate in uncomplicated falciparum malaria. Acta Trop. 2009 Sep;111(3):275-8. [3]. Wang JY, et al. [Therapeutic efficacy of naphthoquine phosphate combined with artemisinine against Plasmodium knowlesi]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2008 Dec 30;26(6):442-444. [4]. Wang JY, et al. Naphthoquine phosphate and its combination with artemisinine. Acta Trop. 2004 Feb;89(3):375-81. [5]. Wang SQ, et al. Therapeutic effect of dihydroartemisinin combined with naphthoquine phosphate in patients with falciparum malaria .Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2002;20(3):180-2. [6]. El-Beshbishi SN, et al. First insight into the effect of single oral dose therapy with artemisinin-naphthoquine phosphate combination in a mouse model of Schistosoma mansoni infection. Int J Parasitol. 2013 Jun;43(7):521-530.

描述

Naphthoquine磷酸盐是抗疟疾化合物。

相关类别

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 其他

参考文献

分子式	C₂₄H₃₄ClN₃O₉P₂
分子量	605.942
精确质量	605.145874
PSA	232.32000
LogP	4.71100
InChIKey	QTYPWHKJEDCDNH-UHFFFAOYSA-N
SMILES	CC(C)(C)NCc1cc(Nc2ccnc3cc(Cl)ccc23)c2c(c1O)CCCC2.O=P(O)(O)O.O=P(O)(O)O
储存条件	2-8℃

1-Naphthalenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]-5,6,7,8-tetrahydro-, phosphate (1:2) (salt)

Naphthoquine phosphate

4-[(7-Chloro-4-quinolinyl)amino]-2-{[(2-methyl-2-propanyl)amino]methyl}-5,6,7,8-tetrahydro-1-naphthalenol phosphate (1:2)

CS-0739

Naphthoquine (phosphate)