去乙酰毛花苷

• 常用名: 去乙酰毛花苷
• 英文名: Deslanoside
• CAS号: 17598-65-1
• 分子量: 943.079
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₄₇H₇₄O₁₉
• 熔点: 220-235ºC
• 闪点: N/A

去乙酰毛花苷用途

Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,用于治疗充血性心力衰竭和因折返机制引起的室上性心律失常,并在治疗慢性心房颤动时控制心室率。Deslanoside 抑制Na-K-ATPase膜泵,导致细胞内钠和钙浓度增加。

去乙酰毛花苷名称

• 中文名: 去乙酰毛花苷
• 英文名: deslanoside
• 中文别名: 毛地黄苷C

去乙酰毛花苷生物活性

• 描述: Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,用于治疗充血性心力衰竭和因折返机制引起的室上性心律失常,并在治疗慢性心房颤动时控制心室率。Deslanoside 抑制Na-K-ATPase膜泵,导致细胞内钠和钙浓度增加。
• 相关类别:
  研究领域 >> 心血管疾病
• 体外研究: 去乙酰甲苷(Desacetyllanatoside C)是兰豆苷C的代谢产物[4]。地塞米松增加前臂血流量和心脏指数,降低心率,同时骨骼肌交感神经活动显著降低,作为中枢介导交感神经系统活动的指标[1]。
• 参考文献:

  [1]. Hauptman PJ, et al. Digitalis. Circulation. 1999 Mar 9;99(9):1265-70.

  [2]. Wang L, et al. Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China. Sci Rep. 2017 Oct 23;7(1):13819.

  [3]. Deslanoside.

  [4]. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8.

  [5]. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8.

去乙酰毛花苷物理化学性质

• 密度: 1.4±0.1 g/cm3
• 熔点: 220-235ºC
• 分子式: C₄₇H₇₄O₁₉
• 分子量: 943.079
• 精确质量: 942.482422
• PSA: 282.21000
• LogP: -1.40
• 折射率: 1.620
• 储存条件: 2-8°C

去乙酰毛花苷毒性和生态

去乙酰毛花苷安全信息

• 风险声明 (欧洲): R23/25
• 安全声明 (欧洲): 1-22-45
• 危险品运输编码: UN 2811

去乙酰毛花苷英文别名

• Card-20(22)-enolide, 3-((O-β-D-glucopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3β,5β,12β)-
• Deacetyllanatoside C
• Desacetyllanatoside C
• Deslanatoside C
• Deslanoside
• Deacetyllanatoside C,Desacetyllanatoside C
• Cedilanide
• (3β,5β,12β)-3-{[β-D-Glucopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• deacetyl-lanatoside
• 4-18-00-02455 (Beilstein Handbook Reference)
• Desacetyldigilanide C
• Descetyldigilanide C
• DESLANOSIDUM
• 4-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-3-{[(2R,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-6-methyl-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2(5H)-furanone
• Desaci
• Desace
• MFCD00135818
• deacetyl-lanatoside C
• Card-20(22)-enolide, 3-[[O-β-D-glucopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12,14-d ihydroxy-, (3β,5β,12β)-
• Deslanatoside
• Purpurea Glycoside C
• Desacetyllanatosid C
• card-20(22)-enolide, 3-[[O-β-D-glucopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• glucodigoxin
• Deslanosidum C
• (3β,5β,12β)-3-{[β-D-Glucopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy}-12,14-dihydro
 xycard-20(22)-enolide
• 4-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-3-{[(2R,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-6-méthyl-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}tétrahydro-2H-pyran-2-yl]oxy}-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-10,13-diméthylhexadécahydro-1H-cyclopenta[a]phénanthrén-17-yl]-2(5H)-furanone
• cedilanidd
• sediranido
• EINECS 241-568-1
• de-O-acetyl-lanatoside C
• 4-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-12,14-Dihydroxy-3-{[(2R,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-5-{[(2S,4S,5S,6R)-4-hydroxy-6-methyl-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-6-methyltetrahydro-2H-pyran-2-yl]oxy}-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2(5H)-furanon