Benzamide, N-[3-[6-amino-5-[[1-(1-oxo-2-propen-1-yl)-3-azetidinyl]oxy]-4-pyrimidinyl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluoro

• 常用名: Benzamide, N-[3-[6-amino-5-[[1-(1-oxo-2-propen-1-yl)-3-azetidinyl]oxy]-4-pyrimidinyl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluoro
• 英文名: Benzamide, N-[3-[6-amino-5-[[1-(1-oxo-2-propen-1-yl)-3-azetidinyl]oxy]-4-pyrimidinyl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluoro
• CAS号: 1787294-00-1
• 分子量: 505.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₅F₂N₅O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: Benzamide, N-[3-[6-amino-5-[[1-(1-oxo-2-propen-1-yl)-3-azetidinyl]oxy]-4-pyrimidinyl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluoro

物理化学性质

• 分子式: C₂₇H₂₅F₂N₅O₃
• 分子量: 505.5
• InChIKey: OSLWRSOLKHYZCC-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1NC(=O)C2=C(C=C(C=C2)C3CC3)F)F)C4=C(C(=NC=N4)N)OC5CN(C5)C(=O)C=C

靶点实验

查看更多实验

实验名称：In vivo protein occupancy at BTK in OFA-1 rat spleen assessed as reduction in biotiny... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4358491

实验名称：Inhibition of BTK in human B cells assessed as reduction in anti-IgM/IL4-stimulated C... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4358489

实验名称：Inhibition of BTK in vitamin D3 differentiated human THP1 cells assessed as inhibitio... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4358488

实验名称：Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-N... 来源：ChEMBL 靶标：Tyrosine-protein kinase BTK External Id：CHEMBL4358487

实验名称：Inhibition of Btk Enzymatic Activity from US Patent US10457647: "Amino pyrimidine der... 来源：BindingDB 靶标：N/A External Id：BindingDB_8763_1

实验名称：Permeability of the compound at pH 6.8 by PAMPA 来源：ChEMBL 靶标：N/A External Id：CHEMBL4358497

实验名称：Half life in human plasma 来源：ChEMBL 靶标：N/A External Id：CHEMBL4358496

实验名称：Oral bioavailability in OFA-1 rat at 10 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL4358495

实验名称：In vivo protein occupancy at BTK in OFA-1 rat spleen assessed as reduction in biotiny... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4358493

实验名称：In vivo protein occupancy at BTK in OFA-1 rat spleen assessed as reduction in biotiny... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4358492

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