BAY-588

• 常用名: BAY-588
• 英文名: BAY-588
• CAS号: 1799759-24-2
• 分子量: 527.51
• 密度: 1.4±0.1 g/cm3
• 沸点: 603.7±55.0 °C at 760 mmHg
• 分子式: C₂₇H₂₅F₄N₅O₂
• 熔点: N/A
• 闪点: 318.9±31.5 °C

BAY-588用途

BAY-588是GLUT1的选择性抑制剂,IC50值为1.18μM。

BAY-588名称

• 英文名: BAY-588

BAY-588生物活性

• 描述: BAY-588是GLUT1的选择性抑制剂,IC50值为1.18μM。
• 相关类别:
  研究领域 >> 代谢疾病
• 靶点实验:

  IC50=1.18μM（GLUT1)[1], IC50>10μM（GLUT2)[1], IC50=5.47μM（GLUT3)[1], IC50=0.5μM（GLUT4)[1]

• 参考文献:

  [1]. Holger Siebeneicher, et, al. Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem. 2016, 11, 20.

BAY-588物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 603.7±55.0 °C at 760 mmHg
• 分子式: C₂₇H₂₅F₄N₅O₂
• 分子量: 527.51
• 闪点: 318.9±31.5 °C
• 精确质量: 527.194458
• LogP: 6.14
• InChIKey: DNGZBWVQLFNTRT-UHFFFAOYSA-N
• SMILES: Cc1c(NC(=O)c2cc(C(N)=O)nc3cc(F)ccc23)c(C(F)(F)F)nn1Cc1ccc(C(C)(C)C)cc1
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.604

BAY-588靶点实验

查看更多实验

实验名称：Inhibition of human GLUT1 expressed in human DLD-1 cells assessed as reduction in glu... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 1 External Id：CHEMBL5658131

实验名称：Inhibition of human GLUT2 expressed in CHO cells assessed as reduction in fructose up... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 2 External Id：CHEMBL5658132

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Inhibition of human GLUT3 expressed in human GLUT1-/- DLD-1 cells assessed as reducti... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 3 External Id：CHEMBL5658133

实验名称：Inhibition of human GLUT4 expressed in CHO cells assessed as reduction in glucose upt... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 4 External Id：CHEMBL5658134

实验名称：Cell viability screening matched tumor and healthy colorectal patient-derived organoi... 来源：ChEMBL 靶标：Colon organoid External Id：CHEMBL5724804

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Redox activity H2DCFDA assay (redox-free) 来源：ChEMBL 靶标：N/A External Id：CHEMBL4880078

实验名称：Redox activity Resazurin assay (0.1 µM compound) 来源：ChEMBL 靶标：N/A External Id：CHEMBL4880077

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BAY-588英文别名

• BAY-588
• 7-Fluoro-N4-{5-methyl-1-[4-(2-methyl-2-propanyl)benzyl]-3-(trifluoromethyl)-1H-pyrazol-4-yl}-2,4-quinolinedicarboxamide
• N4-[1-[[4-(1,1-Dimethylethyl)phenyl]methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide