KLS-13019

• 常用名: KLS-13019
• 英文名: KLS-13019
• CAS号: 1801243-39-9
• 分子量: 355.47
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₉NO₃
• 熔点: N/A
• 闪点: N/A

KLS-13019用途

KLS-13019是一种大麻二酚衍生的神经保护剂,具有改进的功效、安全性和渗透性。(EC50=40nM；T1=7500)。KLS-13019的效力高出50倍,并且>；比大麻二酚安全400倍,并且在体外表现出与提高的口服生物利用度一致的特性。KLS-13019只有在300μ。

KLS-13019名称

• 英文名: KLS-13019

KLS-13019生物活性

• 描述: KLS-13019是一种大麻二酚衍生的神经保护剂,具有改进的功效、安全性和渗透性。(EC50=40nM；T1=7500)。KLS-13019的效力高出50倍,并且>；比大麻二酚安全400倍,并且在体外表现出与提高的口服生物利用度一致的特性。KLS-13019只有在300μ。
• 参考文献: 1. Discovery of KLS-13019, a Cannabidiol-Derived Neuroprotective Agent, with Improved Potency, Safety, and Permeability. William A. Kinney, Mark E. McDonnell, Hua Marlon Zhong, Chaomin Liu, Lanyi Yang, Wei Ling, Tao Qian, Yu Chen, Zhijie Cai, Dean Petkanas, and Douglas E. Brenneman。 Publication Date (Web): February 10, 2016 (Letter)。 DOI: 10.1021/acsmedchemlett.6b00009

KLS-13019物理化学性质

• 分子式: C₂₂H₂₉NO₃
• 分子量: 355.47
• InChIKey: VWVIOABMCXYUAS-RBUKOAKNSA-N
• SMILES: C=C(C)C1CCC(C)=CC1c1c(O)cc(CC2CN(C(C)=O)C2)cc1O

KLS-13019靶点实验

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实验名称：Neuroprotective activity in rat hippocampal neurons assessed as protection against am... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3812692

实验名称：Neuroprotective activity in rat hippocampal neurons assessed as protection against am... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3812691

实验名称：Neuroprotective activity in rat hippocampal neurons assessed as protection against et... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3812690

实验名称：Displacement of [3H]WIN 55212-2 from human recombinant CB2 receptor expressed in CHO ... 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL3812867

实验名称：Displacement of [3H]CP 55940 from human recombinant CB1 receptor expressed in CHO cel... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL3812695

实验名称：Therapeutic index, ratio of TC50 for rat hippocampal neurons to EC50 for protection a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3812694

实验名称：Efflux ratio of permeability from basolateral to apical over apical to basolateral si... 来源：ChEMBL 靶标：MDCK External Id：CHEMBL3812913

实验名称：Apparent permeability from apical to basolateral side in MDCK cells expressing MDR1 来源：ChEMBL 靶标：MDCK External Id：CHEMBL3812912

实验名称：Efflux ratio of permeability from basolateral to apical over apical to basolateral si... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3812911

实验名称：Apparent permeability from apical to basolateral side in human Caco cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL3812910

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