GSK3739936

• 常用名: GSK3739936
• 英文名: GSK3739936
• CAS号: 1803444-21-4
• 分子量: 562.726
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₄₃FN₂O₄
• 熔点: N/A
• 闪点: N/A

GSK3739936用途

GSK3739936(BMS-986180)是一种有效的变构HIV-1整合酶(ALLINI),在体外对大多数124/125变异体(EC50=1.7 nM)表现出极好的效力。

GSK3739936名称

• 英文名: GSK3739936

GSK3739936生物活性

• 描述: GSK3739936(BMS-986180)是一种有效的变构HIV-1整合酶(ALLINI),在体外对大多数124/125变异体(EC50=1.7 nM)表现出极好的效力。
• 参考文献: 1. Naidu BN, et al. J Med Chem. 2022 Mar 24;65(6):4949-4971.

GSK3739936物理化学性质

• 分子式: C₃₄H₄₃FN₂O₄
• 分子量: 562.726

GSK3739936靶点实验

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实验名称：Cardiotoxicity in dog heart assessed as decrease in blood pressure at 300 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL5049401

实验名称：Cardiotoxicity in dog heart assessed as increase in heart rate at 300 mg/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL5049400

实验名称：Cardiotoxicity in dog heart assessed as change in electrocardiographic parameter upto... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5049399

实验名称：Toxicity in rat assessed as histological changes in stomach at 500 mg/kg/day 来源：ChEMBL 靶标：N/A External Id：CHEMBL5049398

实验名称：Mutagenicity in Salmonella Typhimurium using Aroclor 1254 induced rat liver S9 fracti... 来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhimurium External Id：CHEMBL5049405

实验名称：Genotoxicity in Salmonella typhimurium TA102 by Ames test 来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhimurium External Id：CHEMBL5049404

实验名称：Toxicity in rat at 50 to 500 mg/kg in cannulated jugular vein 来源：ChEMBL 靶标：N/A External Id：CHEMBL5049403

实验名称：Toxicity in rat assessed as change in parathyroid gland at 500 mg/kg/day 来源：ChEMBL 靶标：N/A External Id：CHEMBL5049393

实验名称：Toxicity in rat assessed as lipidosis at 500 mg/kg/day 来源：ChEMBL 靶标：N/A External Id：CHEMBL5049392

实验名称：Toxicity in rat assessed as vacuolation of kidney at 500 mg/kg/day 来源：ChEMBL 靶标：N/A External Id：CHEMBL5049391

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