17β-雌二醇17β-D-葡糖苷酸

• 常用名: 17β-雌二醇17β-D-葡糖苷酸
• 英文名: 17β-Estradiol 17β-D-Glucuronide
• CAS号: 1806-98-0
• 分子量: 448.51
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₂O₈
• 熔点: N/A
• 闪点: N/A

17β-雌二醇17β-D-葡糖苷酸用途

雌二醇17-(β-D-葡糖苷酸)是雌激素的代谢产物,众所周知会导致人类肝内胆汁淤积。雌二醇17-(β-D-葡糖苷酸)是oatp有机阴离子转运蛋白的高亲和力底物[1]。

17β-雌二醇17β-D-葡糖苷酸名称

• 中文名: 17β-雌二醇17β-D-葡糖苷酸
• 英文名: 17β-estradiol 17-glucosiduronic acid

17β-雌二醇17β-D-葡糖苷酸生物活性

• 描述: 雌二醇17-(β-D-葡糖苷酸)是雌激素的代谢产物,众所周知会导致人类肝内胆汁淤积。雌二醇17-(β-D-葡糖苷酸)是oatp有机阴离子转运蛋白的高亲和力底物[1]。
• 相关类别:
  研究领域 >> 内分泌
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Kinbara S, et al. Improvement of estradiol-17 beta-D-glucuronide-induced cholestasis by sodium tauroursodeoxycholate therapy in rats. Scand J Gastroenterol. 1997;32(9):947-952.

  [2]. Kanai N,et al. Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 1996 Feb;270(2 Pt 2):F326-31.

17β-雌二醇17β-D-葡糖苷酸物理化学性质

• 分子式: C₂₄H₃₂O₈
• 分子量: 448.51
• 精确质量: 448.21000
• PSA: 136.68000
• LogP: 1.52570
• InChIKey: MTKNDAQYHASLID-QXYWQCSFSA-N
• SMILES: CC12CCC3c4ccc(O)cc4CCC3C1CCC2OC1OC(C(=O)O)C(O)C(O)C1O
• 蒸汽压: 2.34E-20mmHg at 25°C
• 储存条件: -20°C，密闭，干燥

17β-雌二醇17β-D-葡糖苷酸靶点实验

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实验名称：TP_TRANSPORTER: uptake (pH 5.0) of Estradiol-17beta-D-glucuronide at a concentration ... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 2B1 External Id：CHEMBL2077210

实验名称：TP_TRANSPORTER: Transepithelial Transport (basal to apical) in OATP1B1/MRP2 double tr... 来源：ChEMBL 靶标：ATP-binding cassette sub-family C member 2 External Id：CHEMBL2076883

实验名称：Substrate of human UDP-glucuronosyltransferase UGT1A1 来源：ChEMBL 靶标：UDP-glucuronosyltransferase 1A1 External Id：CHEMBL1743324

实验名称：Activity at human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as rate of ... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B3 External Id：CHEMBL2169424

实验名称：Activity at human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as rate of ... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B1 External Id：CHEMBL2169423

实验名称：TP_TRANSPORTER: cell accumulation in OATP2-expressing HEK293 cells 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B1 External Id：CHEMBL2076471

实验名称：TP_TRANSPORTER: cell accumulation in Oatp14-expressing HEK293 cells 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1C1 External Id：CHEMBL2076875

实验名称：TP_TRANSPORTER: uptake (pH 7.4) of Estradiol-17beta-D-glucuronide at a concentration ... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 2B1 External Id：CHEMBL2077201

实验名称：TP_TRANSPORTER: inhibition of DHEAS in membrane vesicles from MRP4-expressing Sf9 cel... 来源：ChEMBL 靶标：ATP-binding cassette sub-family C member 4 External Id：CHEMBL2077067

实验名称：TP_TRANSPORTER: uptake in membrane vesicle from MRP1-expressing HeLa cells 来源：ChEMBL 靶标：Multidrug resistance-associated protein 1 External Id：CHEMBL2076061

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17β-雌二醇17β-D-葡糖苷酸英文别名

• 17β-Estradiol 17β-D-Glucuronide
• [14C]-Estradiol 17beta-glucuronide
• 17beta-estradiol 17-glucosiduronic acid
• 1,3,5(10)-ESTRATRIEN-17ALPHA-ETHYNYL-3,17BETA-DIOL-17BETA-GLUCURONIDE
• 17Beta-Estradiol 17Beta-D-Glucuronide