MAP4K4-IN-17

更新时间：2026-07-16 11:06:25

MAP4K4-IN-17结构式	常用名	MAP4K4-IN-17	英文名	MAP4K4-IN-17
	CAS号	1811510-58-3	分子量	297.746
	密度	N/A	沸点	N/A
	分子式	C₁₅H₁₂ClN₅	熔点	N/A
	MSDS	N/A	闪点	N/A

MAP4K4-IN-17用途

MAP4K4-IN-17是一种有效且高选择性的MAP4K4抑制剂,IC50为14.9 nM,与PF-06260933(一种用于高级临床前开发的先导化合物)相比,显示出改善的整体药物样特性。

英文名	MAP4K4-IN-17

描述	MAP4K4-IN-17是一种有效且高选择性的MAP4K4抑制剂,IC50为14.9 nM,与PF-06260933(一种用于高级临床前开发的先导化合物)相比,显示出改善的整体药物样特性。
参考文献	References 1. Ammirati M, et al. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33. View Related Products by Target MAP4K

分子式	C₁₅H₁₂ClN₅
分子量	297.746
外观性状	固体
储存条件	2-8°C，密封，干燥

实验名称：Toxicity in telemetered rat assessed as induction of weight loss at 25 mg/kg, po BID
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4682013

实验名称：Toxicity in telemetered rat assessed as increase in maximal heart rate at 25 mg/kg, p...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4682015

实验名称：Passive permeability in MDCK2 cell with low efflux
来源：ChEMBL
靶标：N/A
External Id：CHEMBL3755428

实验名称：Toxicity in telemetered rat assessed as increase in body temperature at 25 mg/kg, po ...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4682014

实验名称：Inhibition of human MAP4K4 transfected in 293 MSR cells assessed as inhibition of pho...
来源：ChEMBL
靶标：Mitogen-activated protein kinase kinase kinase kinase 4
External Id：CHEMBL3755427

实验名称：Inhibition of recombinant human MAP4K4 catalytic domain in presence of 10 uM ATP (Km)...
来源：ChEMBL
靶标：Mitogen-activated protein kinase kinase kinase kinase 4
External Id：CHEMBL3755426

实验名称：Solubility of compound at pH 1.2
来源：ChEMBL
靶标：N/A
External Id：CHEMBL3755430

实验名称：Unbound intrinsic clearance in human liver microsomes
来源：ChEMBL
靶标：Liver microsome
External Id：CHEMBL3755436

实验名称：Inhibition of CYP2C9 (unknown origin) at 3 uM
来源：ChEMBL
靶标：Cytochrome P450 2C9
External Id：CHEMBL3755440

实验名称：Inhibition of MAP4K4 in human GripTite 293 MSR cells assessed as reduction in TRAF2 S...
来源：ChEMBL
靶标：Mitogen-activated protein kinase kinase kinase kinase 4
External Id：CHEMBL4681995

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