Y02224

• 常用名: Y02224
• 英文名: Y02224
• CAS号: 1853988-48-3
• 分子量: 461.33
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₇BrN₂O₄S
• 熔点: N/A
• 闪点: N/A

Y02224用途

Y02224是一种BET抑制剂。对白血病细胞具有合理的抗增殖作用。

Y02224名称

• 英文名: Y02224

Y02224生物活性

• 描述: Y02224是一种BET抑制剂。对白血病细胞具有合理的抗增殖作用。
• 参考文献: 1. Xue, X. Q.; Zhang, Y.; Liu, Z. X.; Song, M.; Xing, Y. L.; Xiang, Q. P.; Wang, Z.; Tu, Z. C.; Zhou, Y. L.; Ding, K.; Xu, Y. Discovery of benzo[cd]indol-2(1H)-ones as potent and specific BET bromodomain inhibitors: structure-based virtual screening, optimization

Y02224物理化学性质

• 分子式: C₂₀H₁₇BrN₂O₄S
• 分子量: 461.33
• InChIKey: JTOXINSTQFVILZ-UHFFFAOYSA-N
• SMILES: CCN1C(=O)c2cccc3c(NS(=O)(=O)c4cc(Br)ccc4OC)ccc1c23

Y02224靶点实验

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实验名称：Antiproliferative activity against human HT-29 cells after 72 hrs by CCK8 assay 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL3782664

实验名称：Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3782663

实验名称：Antiproliferative activity against human MV4-11 cells after 72 hrs by CCK8 assay 来源：ChEMBL 靶标：MV4-11 External Id：CHEMBL3782662

实验名称：Binding affinity to human His6-tagged BRD4 bromodomain 1 (N44 to E168 residues) expre... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL3782661

实验名称：Binding affinity to human His6-tagged CREBBP (R1081 to G1197 residues) expressed in E... 来源：ChEMBL 靶标：CREB-binding protein External Id：CHEMBL3782668

实验名称：Binding affinity to human His6-tagged BRD2 bromodomain 1 (K77 to N194 residues) expre... 来源：ChEMBL 靶标：Bromodomain-containing protein 2 External Id：CHEMBL3782667

实验名称：Binding affinity to human His6-tagged BRDT bromodomain 1 (N21 to E137 residues) expre... 来源：ChEMBL 靶标：Bromodomain testis-specific protein External Id：CHEMBL3782666

实验名称：Binding affinity to human His6-tagged ASH1L (E2433 to E2564 residues) expressed in Es... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase ASH1L External Id：CHEMBL3782787

实验名称：Binding affinity to human His6-tagged PCAF (G715 to D831 residues) expressed in Esche... 来源：ChEMBL 靶标：Histone acetyltransferase KAT2B External Id：CHEMBL3782671

实验名称：Binding affinity to human His6-tagged BRD9 (L14 to Q134 residues) expressed in Escher... 来源：ChEMBL 靶标：Bromodomain-containing protein 9 External Id：CHEMBL3782670

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