Fosmetpantotenate

• 常用名: Fosmetpantotenate
• 英文名: Fosmetpantotenate
• CAS号: 1858268-66-2
• 分子量: 474.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₃₁N₂O₉P
• 熔点: N/A
• 闪点: N/A

Fosmetpantotenate用途

氟司马坦酯是一种磷酸泛酸(PPA)前药,旨在在细胞内释放PPA,从而恢复CoA水平。磷磺戊酯用于治疗泛酸激酶相关的神经退行性变。

Fosmetpantotenate名称

• 英文名: Fosmetpantotenate

Fosmetpantotenate生物活性

• 描述: 氟司马坦酯是一种磷酸泛酸(PPA)前药,旨在在细胞内释放PPA,从而恢复CoA水平。磷磺戊酯用于治疗泛酸激酶相关的神经退行性变。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Elbaum D, Beconi MG, Monteagudo E, et al. Fosmetpantotenate (RE-024), a phosphopantothenate replacement therapy for pantothenate kinase-associated neurodegeneration: Mechanism of action and efficacy in nonclinical models. PLoS One. 2018;13(3):e0192028. Published 2018 Mar 9.

  [2]. Klopstock T, Escolar ML, Marshall RD, et al. The FOsmetpantotenate Replacement Therapy (FORT) randomized, double-blind, Placebo-controlled pivotal trial: Study design and development methodology of a novel primary efficacy outcome in patients with pantothenate kinase-associated neurodegeneration. Clin Trials. 2019;16(4):410-418.

Fosmetpantotenate物理化学性质

• 分子式: C₂₀H₃₁N₂O₉P
• 分子量: 474.44