GSK-3β抑制剂1

• 常用名: GSK-3β抑制剂1
• 英文名: GSK-3β inhibitor 1
• CAS号: 187325-53-7
• 分子量: 222.24
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₀N₂O
• 熔点: N/A
• 闪点: N/A

GSK-3β抑制剂1用途

GSK-3β inhibitor 1 (compound 3a) 是糖原合成酶激酶 3β (GSK-3β)的抑制剂,具有治疗糖尿病的潜能,其对 GSK-3β 的 IC50 值为 4.9 nM。

GSK-3β抑制剂1名称

• 中文名: GSK-3β抑制剂1
• 英文名: GSK-3β inhibitor 1

GSK-3β抑制剂1生物活性

• 描述: GSK-3β inhibitor 1 (compound 3a) 是糖原合成酶激酶 3β (GSK-3β)的抑制剂,具有治疗糖尿病的潜能,其对 GSK-3β 的 IC50 值为 4.9 nM。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> GSK-3
  研究领域 >> 代谢疾病
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> GSK-3
• 靶点实验:

  GSK-3β:4.9 nM (IC50)

• 参考文献:

  [1]. Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817.

GSK-3β抑制剂1物理化学性质

• 分子式: C₁₄H₁₀N₂O
• 分子量: 222.24
• 外观性状: 固体
• 储存条件: -20°C

GSK-3β抑制剂1靶点实验

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实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：DNDI: Cytotoxicity against human MRC-5 lung fibroblast cells. 来源：ChEMBL 靶标：MRC5 External Id：CHEMBL2095143

实验名称：DNDI: Inhibition of Human African Trypanosomiasis (HAT), STIB 795, in vitro 来源：ChEMBL 靶标：Trypanosoma brucei brucei External Id：CHEMBL2095144

实验名称：Inhibition of TRKC (unknown origin) at 0.5 uM relative to control 来源：ChEMBL 靶标：NT-3 growth factor receptor External Id：CHEMBL5501741

实验名称：Inhibition of FLT3 (unknown origin) at 0.5 uM relative to control 来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3 External Id：CHEMBL5501740

实验名称：Inhibition of recombinant human GSK3beta at 10 uM using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE... 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL4393035

实验名称：Inhibition of human TLK2 preincubated for 20 mins followed by 33P-ATP addition and me... 来源：ChEMBL 靶标：Serine/threonine-protein kinase tousled-like 2 External Id：CHEMBL5501739

实验名称：Inhibition of recombinant human GSK3beta using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as subst... 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL4393036

实验名称：Cytotoxicity against human PBMC assessed as reduction in cell viability at 0.1 to 10 ... 来源：ChEMBL 靶标：PBMC External Id：CHEMBL4393038

实验名称：Cytotoxicity against human A549 cells assessed as reduction in cell viability measure... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4393039

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