4-[4-(Methylsulfonyl)phenyl]-2-(4-morpholinyl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine

• 常用名: 4-[4-(Methylsulfonyl)phenyl]-2-(4-morpholinyl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine
• 英文名: 4-[4-(Methylsulfonyl)phenyl]-2-(4-morpholinyl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine
• CAS号: 1876466-66-8
• 分子量: 435.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₁N₅O₃S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4-[4-(Methylsulfonyl)phenyl]-2-(4-morpholinyl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine

物理化学性质

• 分子式: C₂₂H₂₁N₅O₃S
• 分子量: 435.5
• InChIKey: FAZDIAPBCWLARY-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)c1ccc(-c2cc(N3CCOCC3)nc3c(-c4ccn[nH]4)nccc23)cc1

靶点实验

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实验名称：Volume of distribution at steady state in Wistar rat at 0.3 to 0.5 mg/kg, iv administ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4612719

实验名称：Clearance in Wistar rat at 0.3 to 0.5 mg/kg, iv administered as bolus dose by LC-MS/M... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4612718

实验名称：Oral bioavailability in Wistar rat at 0.6 to 1 mg/kg by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4612721

实验名称：Apparent half life in Wistar rat at 0.3 to 0.5 mg/kg, iv administered as bolus dose b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4612720

实验名称：Antitumor activity against human HT-29 cells xenografted in po dosed mouse administer... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4612723

实验名称：Antiproliferative activity against human HT-29 cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4612710

实验名称：Apparent permeability across apical to basolateral side in human Caco2 cells at 2 uM ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4612713

实验名称：Clearance in human hepatocytes at 1 uM measured after 2 to 90 mins by LC-MS/MS analys... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4612715

实验名称：Efflux ratio of apparent permeability across basolateral to apical side over apical t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4612714

实验名称：Clearance in rat liver microsomes at 1 uM measured after 2 to 60 mins in presence of ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4612717

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