AG1557

• 常用名: AG1557
• 英文名: AG-1557
• CAS号: 189290-58-2
• 分子量: 407.206
• 密度: 1.7±0.1 g/cm3
• 沸点: 492.9±45.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄IN₃O₂
• 熔点: N/A
• 闪点: 251.9±28.7 °C

AG1557用途

AG-1557,化合物 22 (T),是 ATP 竞争性表皮生长因子受体 (EGFR) 酪氨酸激酶的抑制剂,pIC50 值为 8.194。

AG1557名称

• 英文名: 4-(3'-iodophenyl)-amino-6,7-dimethoxyquinazoline

AG1557生物活性

• 描述: AG-1557,化合物 22 (T),是 ATP 竞争性表皮生长因子受体 (EGFR) 酪氨酸激酶的抑制剂,pIC50 值为 8.194。
• 相关类别:
  信号通路 >> JAK/STAT信号通路 >> EGFR
  研究领域 >> 其他
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 参考文献:

  [1]. Akshada Joshi， et al. Identification of Potential Novel EGFR Inhibitors using a Combination of Pharmacophore and Docking Methods. International Journal of Pharmacy and Pharmaceutical Sciences, ISSN- 0975-1491 Vol 7, Issue 6, 2015

AG1557物理化学性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 492.9±45.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄IN₃O₂
• 分子量: 407.206
• 闪点: 251.9±28.7 °C
• 精确质量: 407.013062
• PSA: 56.27000
• LogP: 4.34
• InChIKey: FGCLAQLIXMAIHT-UHFFFAOYSA-N
• SMILES: COc1cc2ncnc(Nc3cccc(I)c3)c2cc1OC
• 外观性状: 白色固体
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.708
• 储存条件: -20℃

AG1557靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Inhibition of EGFR 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL952131

实验名称：Confirmatory qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinas... 来源：NCGC External Id：IP6K1-f1-cherrypicks

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Kinase Inhibition Assay from Article 10.1021/jm9503613: "Tyrosine Kinase Inhibitors. ... 来源：BindingDB 靶标：N/A External Id：BindingDB_541_1

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

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AG1557英文别名

• N-(3-Iodophenyl)-6,7-dimethoxy-4-quinazolinamine
• ag-1557
• N-(3-iodophenyl)-6,7-dimethoxyquinazolin-4-amine