PARP-1/2-IN-1

更新时间：2026-06-30 17:03:57

PARP-1/2-IN-1用途

PARP-1/2-IN-1是一种有效的PARP-1/2抑制剂,IC50分别为0.51nm和23.11nm。

英文名	PARP-1/2-IN-1

描述	PARP-1/2-IN-1是一种有效的PARP-1/2抑制剂,IC50分别为0.51nm和23.11nm。
相关类别	信号通路 >> 表观遗传学 >> PARP 研究领域 >> 其他信号通路 >> 细胞周期/DNA损伤 >> PARP
靶点实验	PARP:0.51 nM (IC50)
参考文献	[1]. Zhou J, et al. Discovery of Quinazoline-2,4(1H,3H)-dione Derivatives Containing 3-Substituted Piperizines as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J Med Chem. 2021 Nov 8.

分子式	C₂₄H₂₇FN₄O₃
分子量	438.49

实验名称：AUC(0 to t) in BALB/c mouse at 25 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5054915

实验名称：AUC(0 to infinity) in BALB/c mouse at 25 mg/kg, po measured upto 24 hrs by LC-MS/MS a...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5054919

实验名称：AUC(0 to t) in Beagle dog at 0.4 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5054918

实验名称：AUC(0 to t) in Beagle dog at 20 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5054917

实验名称：AUC(0 to t) in Sprague-Dawley rat at 20 mg/kg, po measured upto 24 hrs by LC-MS/MS an...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5054916

实验名称：Half life in Beagle dog at 0.4 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5054907

实验名称：Half life in Beagle dog at 20 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5054906

实验名称：Half life in Sprague-Dawley rat at 20 mg/kg, po measured upto 24 hrs by LC-MS/MS anal...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5054905

实验名称：Half life in BALB/c mouse at 25 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5054904

实验名称：Tmax in Beagle dog at 20 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5054910

共68条，当前第1页，共7页

我想出现在这里：