NFATc1-IN-1

• 常用名: NFATc1-IN-1
• 英文名: NFATc1-IN-1
• CAS号: 1912422-56-0
• 分子量: 375.11
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₃H₈F₂INO₂
• 熔点: N/A
• 闪点: N/A

NFATc1-IN-1用途

NFATc1-IN-1(化合物A04)是RANKL诱导的破骨细胞形成的有效抑制剂,IC50为1.57μM。NFATc1-IN-1通过减少RANKL诱导的NFATc1的核移位显示抗破骨细胞生成作用。NFATc1-IN-1可用于破骨细胞疾病研究[1]。

NFATc1-IN-1名称

• 英文名: NFATc1-IN-1

NFATc1-IN-1生物活性

• 描述: NFATc1-IN-1(化合物A04)是RANKL诱导的破骨细胞形成的有效抑制剂,IC50为1.57μM。NFATc1-IN-1通过减少RANKL诱导的NFATc1的核移位显示抗破骨细胞生成作用。NFATc1-IN-1可用于破骨细胞疾病研究[1]。
• 相关类别:
  研究领域 >> 其他
• 体外研究: NFATc1-IN-1(化合物A04)(0-2.5μM,4天)对破骨细胞的形成和功能表现出强烈的抑制活性,最终转化为骨吸收减少[1]。NFATc1-IN-1(1.5-2.5μM,24小时)阻断NFATc1核易位并降低NFATc1水平[1]。细胞活力测定[1]细胞系：破骨细胞前体RAW 264.7细胞浓度：0、0.5、1.0、1.5、2.0和2.5μM孵育时间：4天结果：浓度为1.5,2.0,2.5微米时,红陷阱阳性多核破骨细胞的数量和大小显著减少。以剂量依赖性方式(在1.5、2.0和2.5μM浓度下)显著抑制破骨细胞的形成,而在高达2.5微米浓度下,对破骨细胞前体细胞无细胞毒性作用。免疫荧光[1]细胞系：RAW264.7细胞浓度：1.5或2.5μ。
• 参考文献:

  [1]. Chen CL, et al. Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption. Eur J Med Chem. 2016 Jul 19;117:70-84.

NFATc1-IN-1物理化学性质

• 分子式: C₁₃H₈F₂INO₂
• 分子量: 375.11

NFATc1-IN-1靶点实验

查看更多实验

实验名称：Inhibition of RANKL-induced NFATc1 protein expression in mouse RAW264.7 cells at 1.5 ... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3813200

实验名称：Inhibition of RANKL-induced osteoclastic bone resorption in mouse RAW264.7 cells asse... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3813199

实验名称：Inhibition of RANKL-induced osteoclastic bone resorption in mouse RAW264.7 cells asse... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3813198

实验名称：Inhibition of RANKL-induced NFATc1 translocation in mouse RAW264.7 cells at 2 uM incu... 来源：ChEMBL 靶标：Nuclear factor of activated T-cells, cytoplasmic 1 External Id：CHEMBL3813197

实验名称：NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L... 来源：DTP/NCI 靶标：N/A External Id：MCF7_OneDose

实验名称：Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability aft... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3813192

实验名称：Cytotoxicity against mouse RAW264.7 cells assessed as survival rate at 2.5 uM after 2... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3813191

实验名称：NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell... 来源：DTP/NCI 靶标：N/A External Id：IGROV1_OneDose

实验名称：Inhibition of RANKL-induced NFATc1 translocation in mouse RAW264.7 cells at 1.5 uM in... 来源：ChEMBL 靶标：Nuclear factor of activated T-cells, cytoplasmic 1 External Id：CHEMBL3813196

实验名称：Inhibition of RANKL-induced osteoclast differentiation in mouse RAW264.7 cells assess... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3813195

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