GMI-1271

• 常用名: GMI-1271
• 英文名: GMI-1271
• CAS号: 1914993-95-5
• 分子量: 1326.493
• 密度: N/A
• 沸点: N/A
• 分子式: C₆₀H₁₀₈N₃NaO₂₇
• 熔点: N/A
• 闪点: N/A

GMI-1271用途

一种新型特异性糖模拟E-选择素拮抗剂,Kd为0.46 uM,IC50为1.75 uM；弱抑制L-选择素(IC50=2.9 uM),P-选择素>10 uM；不仅可以将AML细胞移出保护性生态位而且还阻断NF-κB活化并阻止这种E-选择素介导的化学抗性,从而增强标准化疗的治疗效果；也克服MM转移和化学抗性。血癌2期临床

GMI-1271名称

• 英文名: Sodium (1R,2R,3S,5R)-2-[(6-deoxy-α-L-galactopyranosyl)oxy]-3-ethyl-5-[(38-oxo-2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxa-39-azahentetracontan-41-yl)carbamoyl]cyclohexyl 2-acetamido-3-O-[(1S)-1-carboxylato-2-cyclohexylethyl]-2-deoxy-β-D-galactopyranoside

GMI-1271生物活性

• 描述: 一种新型特异性糖模拟E-选择素拮抗剂,Kd为0.46 uM,IC50为1.75 uM；弱抑制L-选择素(IC50=2.9 uM),P-选择素>10 uM；不仅可以将AML细胞移出保护性生态位而且还阻断NF-κB活化并阻止这种E-选择素介导的化学抗性,从而增强标准化疗的治疗效果；也克服MM转移和化学抗性。血癌2期临床
• 参考文献: References 1. Price TT, et al. Mol Cell Oncol. 2016 Jul 26;4(4):e1214771. 2. Culmer DL, et al. Thromb Haemost. 2017 Jun 2;117(6):1171-1181. 3. Natoni A, et al. Leukemia. 2017 Apr 25. doi: 10.1038/leu.2017.123. 4. Dutta P, et al. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1802-8. View Related Products by Target Selectin Blood Cancer

GMI-1271物理化学性质

• 分子式: C₆₀H₁₀₈N₃NaO₂₇
• 分子量: 1326.493
• 精确质量: 1325.706787

GMI-1271英文别名

• Sodium (1R,2R,3S,5R)-2-[(6-deoxy-α-L-galactopyranosyl)oxy]-3-ethyl-5-[(38-oxo-2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxa-39-azahentetracontan-41-yl)carbamoyl]cyclohexyl 2-acetamido-3-O-[(1S)-1-car boxylato-2-cyclohexylethyl]-2-deoxy-β-D-galactopyranoside
• β-D-Galactopyranoside, (1R,2R,3S,5R)-2-[(6-deoxy-α-L-galactopyranosyl)oxy]-5-(1,6-dioxo-9,12,15,18,21,24,27,30,33,36,39,42-dodecaoxa-2,5-diazatritetracont-1-yl)-3-ethylcyclohexyl 2-(acetylamino )-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-2-deoxy-, sodium salt (1:1)