6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(1-methyl-1H-pyrazol-4-yl)methyl]-1-(3-oxetanylmethyl)-2,4-dioxo

• 常用名: 6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(1-methyl-1H-pyrazol-4-yl)methyl]-1-(3-oxetanylmethyl)-2,4-dioxo
• 英文名: 6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(1-methyl-1H-pyrazol-4-yl)methyl]-1-(3-oxetanylmethyl)-2,4-dioxo
• CAS号: 1945951-55-2
• 分子量: 459.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₅N₅O₅S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 6-Quinazolinesulfonamide, 1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(1-methyl-1H-pyrazol-4-yl)methyl]-1-(3-oxetanylmethyl)-2,4-dioxo

物理化学性质

• 分子式: C₂₁H₂₅N₅O₅S
• 分子量: 459.5
• InChIKey: VBAAHLXSBGINKC-UHFFFAOYSA-N
• SMILES: CC1(CC1)NS(=O)(=O)C2=CC3=C(C=C2)N(C(=O)N(C3=O)CC4=CN(N=C4)C)CC5COC5

靶点实验

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实验名称：Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chain... 来源：ChEMBL 靶标：Poly(ADP-ribose) glycohydrolase External Id：CHEMBL4265323

实验名称：Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 1... 来源：ChEMBL 靶标：Poly(ADP-ribose) glycohydrolase External Id：CHEMBL4265322

实验名称：Apparent permeability across apical to basolateral side in human Caco2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4265333

实验名称：Efflux ratio of apparent permeability in human Caco2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4265334

实验名称：Selectivity ratio of cytotoxicity for human HeLa cells to EC50 for human full length ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4265329

实验名称：Clearance in mouse liver microsomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL4265331

实验名称：Clearance in human liver microsomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL4265330

实验名称：Half life in CD1 mouse at 1 mg/kg, iv administered as single dose by LC-MS/MS analysi... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4265341

实验名称：AUC in CD1 mouse at 1 mg/kg, iv administered as single dose by LC-MS/MS analysis 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4265340

实验名称：Clearance in CD1 mouse at 1 mg/kg, iv administered as single dose by LC-MS/MS analysi... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4265343

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