N-[(6-amino-2-methylpyridin-3-yl)methyl]-2-[6-methyl-2-oxo-3-(2-phenylethylamino)pyrazin-1-yl]acetamide

• 常用名: N-[(6-amino-2-methylpyridin-3-yl)methyl]-2-[6-methyl-2-oxo-3-(2-phenylethylamino)pyrazin-1-yl]acetamide
• 英文名: N-[(6-amino-2-methylpyridin-3-yl)methyl]-2-[6-methyl-2-oxo-3-(2-phenylethylamino)pyrazin-1-yl]acetamide
• CAS号: 199294-70-7
• 分子量: 406.48100
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₆N₆O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[(6-amino-2-methylpyridin-3-yl)methyl]-2-[6-methyl-2-oxo-3-(2-phenylethylamino)pyrazin-1-yl]acetamide

物理化学性质

• 分子式: C₂₂H₂₆N₆O₂
• 分子量: 406.48100
• 精确质量: 406.21200
• PSA: 119.15000
• LogP: 2.65170
• InChIKey: PVDHYBJORRALSQ-UHFFFAOYSA-N
• SMILES: Cc1nc(N)ccc1CNC(=O)Cn1c(C)cnc(NCCc2ccccc2)c1=O

靶点实验

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实验名称：Inhibitory activity against thrombin (IIa) was determined 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL817242

实验名称：In vivo area under curve was calculated by peroral administration at 1 mg/kg in faste... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL622570

实验名称：AUC in dog after oral dose (1 mg/kg) 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL622571

实验名称：AUC in dog at 0.5 mg/kg, po 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL4196327

实验名称：in vitro anticoagulant potency (2x APTT) against Human plasma. 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL841955

实验名称：Half life in dog at 0.5 mg/kg, po 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL4196326

实验名称：Inhibitory constant evaluated against thrombin (Factor IIa) 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL814972

实验名称：Inhibition of human thrombin assessed as release of p-nitroanilide from chromogenic s... 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL4196329

实验名称：Inhibitory potency against human thrombin 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL813626

实验名称：Inhibition of human trypsin assessed as release of p-nitroanilide from chromogenic su... 来源：ChEMBL 靶标：Trypsin-3 External Id：CHEMBL4196328

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