1-(2’-O,4-C-甲桥-BETA-D-呋喃核糖基)尿苷

• 常用名: 1-(2’-O,4-C-甲桥-BETA-D-呋喃核糖基)尿苷
• 英文名: 2’-O,4’-C-Methyleneuridine
• CAS号: 200435-92-3
• 分子量: 256.21200
• 密度: 1.695g/cm3
• 沸点: N/A
• 分子式: C₁₀H₁₂N₂O₆
• 熔点: N/A
• 闪点: N/A

用途

2’-O,4’-C-Methyleneuridine (Compound 15a) 是一种双环核苷。

名称

• 中文名: 1-(2’-O,4-C-甲桥-BETA-D-呋喃核糖基)尿苷
• 英文名: 1-[(1R,4S,6R,7S)-7-hydroxy-4-(hydroxymethyl)-2,5-dioxabicyclo[2.2 .1]heptan-6-yl]pyrimidine-2,4-dione
• 中文别名: 1-(2-O,4-C-甲桥-beta-D-呋喃核糖基)尿嘧啶核苷

生物活性

• 描述: 2’-O,4’-C-Methyleneuridine (Compound 15a) 是一种双环核苷。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Sharma VK, et al. Chemoenzymatic convergent synthesis of 2'-O,4'-C-methyleneribonucleosides. J Org Chem. 2014 Jul 3;79(13):6336-41.

物理化学性质

• 密度: 1.695g/cm3
• 分子式: C₁₀H₁₂N₂O₆
• 分子量: 256.21200
• 精确质量: 256.07000
• PSA: 114.04000
• InChIKey: KNLNWXXWKDEEFW-JIOCBJNQSA-N
• SMILES: O=c1ccn(C2OC3(CO)COC2C3O)c(=O)[nH]1
• 储存条件: 2-8℃

靶点实验

查看更多实验

实验名称：Cytotoxicity against human HuH7 cells up to 100 uM after 3 hrs by CellTiter-Blue cell... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3291656

实验名称：Antiviral activity against wild type Hepatitis C virus genotype 1b infected in human ... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL3291655

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英文别名

• 2-(5''-Phosphoribosyl)-5'-amp
• (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-2,5-dioxabicyclo[2.2.1]heptane uracil
• Ado(P)-Rib-P
• (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane
• Ribosyladenosine 5',5''-bis(phosphate)
• 2'-(5-phosphoribosyl)adenosine 5'-monophosphate
• 2'-O,4'-C-methyleneuridine
• 2'-(5''-Phosphoribosyl)-5'-adenosine monophosphate