(2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

• 常用名: (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
• 英文名: (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
• CAS号: 2010986-87-3
• 分子量: 486.6
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₃₄N₄O₄S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

物理化学性质

• 分子式: C₂₅H₃₄N₄O₄S
• 分子量: 486.6
• InChIKey: JAHUHEDUDMTTTF-COWZOJLOSA-N
• SMILES: CC(=O)NC(C(=O)N1CC(O)CC1C(=O)NC(C)c1ccc(-c2scnc2C)cc1)C(C)(C)C

靶点实验

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实验名称：Antiproliferative activity against human A2780 cells incubated for 72 hrs in carbon-d... 来源：ChEMBL 靶标：A2780 External Id：CHEMBL5317289

实验名称：Protac activity at VHL/NAMPT in human A2780 cells assessed as degradation of NAMPT us... 来源：ChEMBL 靶标：von Hippel-Lindau disease tumor suppressor External Id：CHEMBL5317288

实验名称：Competitive binding affinity to His-tagged VHL/Elongin C/Elongin B (unknown origin) b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5540174

实验名称：Competitive binding affinity to His-tagged VHL/Elongin C/Elongin B/KRAS G12D mutant (... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5540175

实验名称：Oral absorption in female C57Bl/6 mouse at 10 mg/kg measured upto 8 hrs by LC-MS/MS a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5511968

实验名称：Cooperativity factor alpha, ratio of IC50 for His-tagged VHL/Elongin C/Elongin B (unk... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5540176

实验名称：Oral bioavailability in female C57Bl/6 mouse at 10 mg/kg measured upto 8 hrs by LC-MS... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5511967

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