M4076

• 常用名: M4076
• 英文名: M4076
• CAS号: 2020089-41-0
• 分子量: 448.458
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₁FN₆O₃
• 熔点: N/A
• 闪点: N/A

M4076用途

M4076是一种高效、选择性ATP竞争性ATM激酶抑制剂,IC50为0.2 nM。M4076在体外使肿瘤细胞系对放射治疗敏感,并在体内强烈增强电离辐射的抗肿瘤活性。

M4076名称

• 英文名: M4076

M4076生物活性

• 描述: M4076是一种高效、选择性ATP竞争性ATM激酶抑制剂,IC50为0.2 nM。M4076在体外使肿瘤细胞系对放射治疗敏感,并在体内强烈增强电离辐射的抗肿瘤活性。
• 参考文献: 1. Stakyte K, et al. Nat Struct Mol Biol. 2021 Oct;28(10):789-798. 2. Thomas Fuchss, et al. Cancer Res (2019) 79 (13_Supplement): 3500.

M4076物理化学性质

• 分子式: C₂₃H₂₁FN₆O₃
• 分子量: 448.458

M4076靶点实验

查看更多实验

实验名称：ATM Kinase Assay from US Patent US11608338: "Imidazolonylquinolines and the use there... 来源：BindingDB 靶标：N/A External Id：BindingDB_11184_1

实验名称：ATM Kinase Assay from US Patent US10745399: "Imidazolonylquinolines and the use there... 来源：BindingDB 靶标：N/A External Id：BindingDB_9336_2

实验名称：ATM Kinase Assay Determination of ATM Inhibition (IC50 ATM) from US Patent US10745399... 来源：BindingDB 靶标：N/A External Id：BindingDB_9336_1

实验名称：PI3K p110alpha/p85alpha (Human), Non-radioactive Assay from US Patent US10457677: "Im... 来源：BindingDB 靶标：N/A External Id：BindingDB_8768_2

实验名称：ATM kinase assay—determination of ATM inhibition (IC50 ATM) from US Patent US104... 来源：BindingDB 靶标：N/A External Id：BindingDB_8768_1

实验名称：mTOR (Human) assay from US Patent US10457677: "Imidazolonylquinolines and the use the... 来源：BindingDB 靶标：N/A External Id：BindingDB_8768_6

实验名称：PI3K (p120gamma) (Human), Non-radioactive Assay from US Patent US10457677: "Imidazolo... 来源：BindingDB 靶标：N/A External Id：BindingDB_8768_5

实验名称：PI3K p110beta/p85alpha (Human), Non-radioactive Assay from US Patent US10457677: "Imi... 来源：BindingDB 靶标：N/A External Id：BindingDB_8768_3

实验名称：ATM Kinase Assay from US Patent US10745399: "Imidazolonylquinolines and the use there... 来源：BindingDB 靶标：N/A External Id：BindingDB_9336_6

实验名称：ATM Kinase Assay from US Patent US10745399: "Imidazolonylquinolines and the use there... 来源：BindingDB 靶标：N/A External Id：BindingDB_9336_5

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