AZD5718

• 常用名: AZD5718
• 英文名: AZD5718
• CAS号: 2041075-86-7
• 分子量: 446.511
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₆N₆O₃
• 熔点: N/A
• 闪点: N/A

AZD5718用途

AZD5718(AZD-5718,AZD 5718)是一种新型有效的5-脂氧合酶激活蛋白(FLAP)抑制剂,结合IC50为6.3 nM；在人全血检测中表现出LTB4抑制,IC50为39 nM；减少促炎和血管活性白三烯的产生。体外和体内。

AZD5718名称

• 英文名: AZD5718

AZD5718生物活性

• 描述: AZD5718(AZD-5718,AZD 5718)是一种新型有效的5-脂氧合酶激活蛋白(FLAP)抑制剂,结合IC50为6.3 nM；在人全血检测中表现出LTB4抑制,IC50为39 nM；减少促炎和血管活性白三烯的产生。体外和体内。
• 参考文献: References 1. Ericsson H, et al. Clin Transl Sci. 2018 May;11(3):330-338. 2. Pettersen D, et al. J Med Chem. 2019 Mar 14. doi: 10.1021/acs.jmedchem.8b02004. View Related Products by Target FLAP

AZD5718物理化学性质

• 分子式: C₂₄H₂₆N₆O₃
• 分子量: 446.511
• InChIKey: ROTWSDMXHVGAHZ-QZTJIDSGSA-N
• SMILES: Cc1cc(-c2ccc(C(=O)C3CCCCC3C(=O)Nc3cnn4c3C(=O)NCC4)cc2)n[nH]1

AZD5718靶点实验

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实验名称：Intrinsic clearance in rat hepatocytes assessed per million cells at 1 uM measured af... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4393792

实验名称：Passive apparent permeability across apical to basolateral side in human Caco2 cells ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4393793

实验名称：Mutagenicity in Salmonella typhimurium TA98 in presence of rat S9 fraction by Ames te... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4393794

实验名称：Mutagenicity in Salmonella typhimurium TA98 in absence of rat S9 fraction by Ames tes... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4393795

实验名称：Mutagenicity in Salmonella typhimurium TA100 in presence of rat S9 fraction by Ames t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4393796

实验名称：Mutagenicity in Salmonella typhimurium TA100 in absence of rat S9 fraction by Ames te... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4393797

实验名称：Octanol-phosphate buffer partition co-efficient, log D of the compound at pH 7.4 afte... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4393787

实验名称：Intrinsic clearance in human hepatocytes assessed per million cells at 1 uM measured ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4393791

实验名称：Protein binding in human plasma assessed as unbound fraction by equilibrium dialysis ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4393825

实验名称：Protein binding in Sprague-Dawley rat plasma assessed as unbound fraction by equilibr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4393826

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