MS012

• 常用名: MS012
• 英文名: MS012
• CAS号: 2089617-83-2
• 分子量: 401.555
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₃₅N₅O₂
• 熔点: N/A
• 闪点: N/A

MS012用途

MS012是G9a样蛋白(GLP)赖氨酸甲基转移酶的有效和选择性抑制剂,IC50为7nM,对GLP的选择性比G9a和其他甲基转移酶高>30倍。

MS012名称

• 英文名: MS012

MS012生物活性

• 描述: MS012是G9a样蛋白(GLP)赖氨酸甲基转移酶的有效和选择性抑制剂,IC50为7nM,对GLP的选择性比G9a和其他甲基转移酶高>30倍。
• 参考文献: References 1. Xiong Y, et al. J Med Chem. 2017 Mar 9;60(5):1876-1891. View Related Products by Target Histone Methyltransferase (HMTase)

MS012物理化学性质

• 分子式: C₂₂H₃₅N₅O₂
• 分子量: 401.555
• InChIKey: ZYNUWSFRZCRKSN-UHFFFAOYSA-N
• SMILES: CCCCCCNc1nc(NC2CCN(C)CC2)c2cc(OC)c(OC)cc2n1

MS012靶点实验

查看更多实验

实验名称：Selectivity ratio of IC50 for recombinant G9a catalytic SET domain (913 to 1193 resid... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4005606

实验名称：Inhibition of recombinant GLP catalytic SET domain (982 to 1266 residues) (unknown or... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT1 External Id：CHEMBL4005670

实验名称：Competitive inhibition of recombinant GLP catalytic SET domain (982 to 1266 residues)... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT1 External Id：CHEMBL4005669

实验名称：Inhibition of DNMT3B/3L (unknown origin) at 1 uM using biotin-labeled peptide as subs... 来源：ChEMBL 靶标：DNA (cytosine-5)-methyltransferase 3-like External Id：CHEMBL4005664

实验名称：Inhibition of DNMT3A/3L (unknown origin) at 1 uM using biotin-labeled peptide as subs... 来源：ChEMBL 靶标：DNA (cytosine-5)-methyltransferase 3-like External Id：CHEMBL4005663

实验名称：Inhibition of METTL3-14 (unknown origin) at 1 uM using biotin-labeled peptide as subs... 来源：ChEMBL 靶标：N6-adenosine-methyltransferase non-catalytic subunit External Id：CHEMBL4005666

实验名称：Inhibition of BCDIN3D (unknown origin) at 1 uM using biotin-labeled peptide as substr... 来源：ChEMBL 靶标：RNA 5'-monophosphate methyltransferase External Id：CHEMBL4005665

实验名称：Inhibition of recombinant G9a catalytic SET domain (913 to 1193 residues) (unknown or... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT2 External Id：CHEMBL4005608

实验名称：Permeability in human Caco2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL4005672

实验名称：Selectivity ratio of Kd for recombinant G9a catalytic SET domain (913 to 1193 residue... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4005671

共39条，当前第1页，共4页

1

2

3

4